Abstract
Developments relating to cobalamin and folate are reviewed. Current work on the relations between these two coenzymes are discussed, particularly those that have emerged in studies using nitrous oxide, which inactivates cobalamin.
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- ABELS J., BOUMA W., NIEWEG H. O. Assay of intrinsic factor with anti-intrinsic factor serum in vitro. Biochim Biophys Acta. 1963 Apr 2;71:227–229. doi: 10.1016/0006-3002(63)91016-3. [DOI] [PubMed] [Google Scholar]
- ARDEMAN S., CHANARIN I. A METHOD FOR THE ASSAY OF HUMAN GASTRIC INTRINSIC FACTOR AND FOR THE DETECTION AND TITRATION OF ANTIBODIES AGAINST INTRINSIC FACTOR. Lancet. 1963 Dec 28;2(7322):1350–1354. doi: 10.1016/s0140-6736(63)90736-0. [DOI] [PubMed] [Google Scholar]
- BAKER H., HERBERT V., FRANK O., PASHER I., HUTNER S. H., WASSERMAN L. R., SOBOTKA H. A microbiologic method for detecting folic acid deficiency in man. Clin Chem. 1959 Aug;5(4):275–280. [PubMed] [Google Scholar]
- Begley J. A., Trachtenberg A. An assay for intrinsic factor based on blocking of the R binder of gastric juice by cobinamide. Blood. 1979 Apr;53(4):788–793. [PubMed] [Google Scholar]
- Brody T., Watson J. E., Stokstad E. L. Folate pentaglutamate and folate hexaglutamate mediated one-carbon metabolism. Biochemistry. 1982 Jan 19;21(2):276–282. doi: 10.1021/bi00531a012. [DOI] [PubMed] [Google Scholar]
- Brugge W. R., Goff J. S., Allen N. C., Podell E. R., Allen R. H. Development of a dual label Schilling test for pancreatic exocrine function based on the differential absorption of cobalamin bound to intrinsic factor and R protein. Gastroenterology. 1980 May;78(5 Pt 1):937–949. [PubMed] [Google Scholar]
- CHAIET L., ROSENBLUM C., WOODBURY D. T. Biosynthesis of radioactive vitamin B12 containing cobalt 60. Science. 1950 Jun 2;111(2892):601–602. doi: 10.1126/science.111.2892.601. [DOI] [PubMed] [Google Scholar]
- Chanarin I., James D. Humoral and cell-mediated intrinsic-factor antibody in pernicious anaemia. Lancet. 1974 Jun 1;1(7866):1078–1080. doi: 10.1016/s0140-6736(74)90556-x. [DOI] [PubMed] [Google Scholar]
- Chanarin I., Muir M. Demonstration of vitamin B12 analogues in human sera not detected by microbiological assay. Br J Haematol. 1982 May;51(1):171–173. doi: 10.1111/j.1365-2141.1982.tb07301.x. [DOI] [PubMed] [Google Scholar]
- Chanarin I., Perry J. Evidence for reduction and methylation of folate in the intestine during normal absorption. Lancet. 1969 Oct 11;2(7624):776–778. doi: 10.1016/s0140-6736(69)90483-8. [DOI] [PubMed] [Google Scholar]
- Chanarin I., Waters D. A. Failed Schilling tests. Scand J Haematol. 1974;12(4):245–248. doi: 10.1111/j.1600-0609.1974.tb00205.x. [DOI] [PubMed] [Google Scholar]
- Dawson D. W., Sawers A. H., Sharma R. K. Malabsorption of protein bound vitamin B12. Br Med J (Clin Res Ed) 1984 Mar 3;288(6418):675–678. doi: 10.1136/bmj.288.6418.675. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Deacon R., Lumb M., Perry J., Chanarin I., Minty B., Halsey M. J., Nunn J. F. Selective inactivation of vitamin B12 in rats by nitrous oxide. Lancet. 1978 Nov 11;2(8098):1023–1024. doi: 10.1016/s0140-6736(78)92341-3. [DOI] [PubMed] [Google Scholar]
- Doscherholmen A., McMahon J., Ripley D. Inhibitory effect of eggs on vitamin B12 absorption: description of a simple ovalbumin 57Co-vitamin B12 absorption test. Br J Haematol. 1976 Jun;33(2):261–272. doi: 10.1111/j.1365-2141.1976.tb03537.x. [DOI] [PubMed] [Google Scholar]
- Green R., Newmark P. A., Musso A. M., Mollin D. L. The use of chicken serum for measurement of serum vitamin B12 concentration by radioisotope dilution: discription of method and comparison with microbiological assay results. Br J Haematol. 1974 Jul;27(3):507–526. doi: 10.1111/j.1365-2141.1974.tb06816.x. [DOI] [PubMed] [Google Scholar]
- HANSEN H. A., NYSTROM B. Blood folic acid levels and folic acid clearance in geriatric cases. Gerontol Clin (Basel) 1961;3:173–182. doi: 10.1159/000244680. [DOI] [PubMed] [Google Scholar]
- HERBERT V., ZALUSKY R. Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies. J Clin Invest. 1962 Jun;41:1263–1276. doi: 10.1172/JCI104589. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heyssel R. M., Bozian R. C., Darby W. J., Bell M. C. Vitamin B12 turnover in man. The assimilation of vitamin B12 from natural foodstuff by man and estimates of minimal daily dietary requirements. Am J Clin Nutr. 1966 Mar;18(3):176–184. doi: 10.1093/ajcn/18.3.176. [DOI] [PubMed] [Google Scholar]
- KILLMANN S. A. EFFECT OF DEOXYURIDINE ON INCORPORATION OF TRITIATED THYMIDINE: DIFFERENCE BETWEEN NORMOBLASTS AND MEGALOBLASTS. Acta Med Scand. 1964 Apr;175:483–488. doi: 10.1111/j.0954-6820.1964.tb00597.x. [DOI] [PubMed] [Google Scholar]
- Katz M., Lee S. K., Cooper B. A. Vitamin B 12 malabsorption due to a biologically inert intrinsic factor. N Engl J Med. 1972 Aug 31;287(9):425–429. doi: 10.1056/NEJM197208312870902. [DOI] [PubMed] [Google Scholar]
- Kolhouse J. F., Kondo H., Allen N. C., Podell E., Allen R. H. Cobalamin analogues are present in human plasma and can mask cobalamin deficiency because current radioisotope dilution assays are not specific for true cobalamin. N Engl J Med. 1978 Oct 12;299(15):785–792. doi: 10.1056/NEJM197810122991501. [DOI] [PubMed] [Google Scholar]
- LUHBY A. L., COOPERMAN J. M., TELLER D. N. Histidine metabolic loading test to distinguish folic acid deficiency from vit. B12 in megaloblastic anemias. Proc Soc Exp Biol Med. 1959 Jun;101(2):350–352. doi: 10.3181/00379727-101-24936. [DOI] [PubMed] [Google Scholar]
- Lumb M., Chanarin I., Perry J., Deacon R. Turnover of the methyl moiety of 5-methyltetrahydropteroylglutamic acid in the cobalamin-inactivated rat. Blood. 1985 Nov;66(5):1171–1175. [PubMed] [Google Scholar]
- MOLLIN D. L., ROSS G. I. M. The vitamin B12 concentrations of serum and urine of normals and of patients with megaloblastic anaemias and other diseases. J Clin Pathol. 1952 May;5(2):129–139. doi: 10.1136/jcp.5.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Metz J., Kelly A., Swett V. C., Waxman S., Herbert V. Deranged DNA synthesis by bone marrow from vitamin B-12-deficient humans. Br J Haematol. 1968 Jun;14(6):575–592. doi: 10.1111/j.1365-2141.1968.tb00364.x. [DOI] [PubMed] [Google Scholar]
- Muir M., Chanarin I. Separation of cobalamin analogues in human sera binding to intrinsic factor and to R-type vitamin B12 binders. Br J Haematol. 1983 Aug;54(4):613–621. doi: 10.1111/j.1365-2141.1983.tb02141.x. [DOI] [PubMed] [Google Scholar]
- Muir M., Chanarin I. Solid-phase vitamin B12 assays using polyacrylamide-bound intrinsic factor and polyacrylamide-bound R-binder. Br J Haematol. 1983 Mar;53(3):423–435. doi: 10.1111/j.1365-2141.1983.tb02043.x. [DOI] [PubMed] [Google Scholar]
- Pearson A. G., Turner A. J. Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase. Nature. 1975 Nov 13;258(5531):173–174. doi: 10.1038/258173a0. [DOI] [PubMed] [Google Scholar]
- Perry J., Chanarin I., Deacon R., Lumb M. Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat. J Clin Invest. 1983 May;71(5):1183–1190. doi: 10.1172/JCI110867. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raven J. L., Robson M. B. Experience with a commercial kit for the radioisotopic assay of vitamin B12 in serum: the Phadebas B12 test. J Clin Pathol. 1974 Jan;27(1):59–65. doi: 10.1136/jcp.27.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raven J. L., Robson M. B., Morgan J. O., Hoffbrand A. V. Comparison of three methods for measuring vitamin B 12 in serum: radioisotopic, euglena gracilis and Lactobacillus leichmannii. Br J Haematol. 1972 Jan;22(1):21–31. doi: 10.1111/j.1365-2141.1972.tb08783.x. [DOI] [PubMed] [Google Scholar]
- Rose M. S., Doniach D., Chanarin I., Brostoff J., Ardeman S. Intrinsic-factor antibodies in absence of pernicious anaemia. 3-7 year follow-up. Lancet. 1970 Jul 4;2(7662):9–12. doi: 10.1016/s0140-6736(70)92473-6. [DOI] [PubMed] [Google Scholar]
- Scott J. M., Dinn J. J., Wilson P., Weir D. G. Pathogenesis of subacute combined degeneration: a result of methyl group deficiency. Lancet. 1981 Aug 15;2(8242):334–337. doi: 10.1016/s0140-6736(81)90649-8. [DOI] [PubMed] [Google Scholar]
- Sourial N. A., Brown L. Regulation of cobalamin and folate metabolism by methionine in human bone marrow cultures. Scand J Haematol. 1983 Nov;31(5):413–423. doi: 10.1111/j.1600-0609.1983.tb01536.x. [DOI] [PubMed] [Google Scholar]
- Taylor R. T., Hanna M. L. Folate-dependent enzymes in cultured Chinese hamster cells: folypolyglutamate synthetase and its absence in mutants auxotrophic for glycine + adenosine + thymidine. Arch Biochem Biophys. 1977 May;181(1):331–334. doi: 10.1016/0003-9861(77)90512-4. [DOI] [PubMed] [Google Scholar]
- van der Westhuyzen J., Fernandes-Costa F., Metz J. Cobalamin inactivation by nitrous oxide produces severe neurological impairment in fruit bats : protection by methionine and aggravation by folates. Life Sci. 1982 Nov 1;31(18):2001–2010. doi: 10.1016/0024-3205(82)90039-x. [DOI] [PubMed] [Google Scholar]