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. 1987 Dec;40(12):1413–1417. doi: 10.1136/jcp.40.12.1413

Unusual immunophenotype displayed by histiocytes in haemophagocytic lymphohistiocystosis.

T Herlin 1, G Pallesen 1, T Kristensen 1, N Clausen 1
PMCID: PMC1141275  PMID: 3323248

Abstract

Extensive immunophenotypic studies in a 2 1/2 month old girl with haemophagocytic lymphohistiocytosis were performed to characterise the proliferating histiocytes of the disease. The cells strongly expressed conventional macrophage antigens, but unexpectedly, there was a dissociated expression of the CD1a antigen (reacting with the monoclonal antibody NA1/34 but not with OKT6) and intracellular S-100 protein by the haemophagocytic lymphohistiocytosis histiocytes. These findings indicate that there is a "hybrid" phenotype between the two main arms of the mononuclear phagocyte system--namely, Langerhans' cells and phagocytic macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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