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. 1987 Dec;40(12):1449–1455. doi: 10.1136/jcp.40.12.1449

Malignant melanotic schwannoma of the bronchus.

D Rowlands 1, C Edwards 1, F Collins 1
PMCID: PMC1141282  PMID: 3429674

Abstract

A case of malignant melanotic schwannoma arising in the right upper lobe bronchus of a 27 year old man is presented. Tumours of this type most commonly occur in spinal nerve roots and are generally considered to be benign. The behaviour of those originating elsewhere is less predictable. As far as we are aware this is the first reported case affecting the respiratory tract.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Angel R., Prados M. Primary bronchial melanoma. J La State Med Soc. 1984 Jun;136(6):13–15. [PubMed] [Google Scholar]
  2. Assor D. A melanocytic tumor of the esophagus. Cancer. 1975 May;35(5):1438–1443. doi: 10.1002/1097-0142(197505)35:5<1438::aid-cncr2820350530>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  3. Bird C. C., Willis R. A. The histogenesis of pigmented neurofibromas. J Pathol. 1969 Apr;97(4):631–637. doi: 10.1002/path.1710970407. [DOI] [PubMed] [Google Scholar]
  4. Burns D. K., Silva F. G., Forde K. A., Mount P. M., Clark H. B. Primary melanocytic schwannoma of the stomach. Evidence of dual melanocytic and schwannian differentiation in an extra-axial site in a patient without neurofibromatosis. Cancer. 1983 Oct 15;52(8):1432–1441. doi: 10.1002/1097-0142(19831015)52:8<1432::aid-cncr2820520816>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  5. Carstens P. H., Kuhns J. G., Ghazi C. Primary malignant melanomas of the lung and adrenal. Hum Pathol. 1984 Oct;15(10):910–914. doi: 10.1016/s0046-8177(84)80119-7. [DOI] [PubMed] [Google Scholar]
  6. Chitale A. R., Dickersin G. R. Electron microscopy in the diagnosis of malignant schwannomas. A report of six cases. Cancer. 1983 Apr 15;51(8):1448–1461. doi: 10.1002/1097-0142(19830415)51:8<1448::aid-cncr2820510819>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  7. Christensen C. Malignant melanocytic schwannoma. A case report. Acta Chir Scand. 1986 May;152:385–386. [PubMed] [Google Scholar]
  8. Chumas J. C., Lorelle C. A. Pulmonary meningioma. A light- and electron-microscopic study. Am J Surg Pathol. 1982 Dec;6(8):795–801. [PubMed] [Google Scholar]
  9. D'Abrera V. S., Burfitt-Williams W. A melanotic neuroectodermal neoplasm of the posterior mediastinum. J Pathol. 1973 Nov;111(3):165–172. doi: 10.1002/path.1711110304. [DOI] [PubMed] [Google Scholar]
  10. Daimaru Y., Hashimoto H., Enjoji M. Malignant peripheral nerve-sheath tumors (malignant schwannomas). An immunohistochemical study of 29 cases. Am J Surg Pathol. 1985 Jun;9(6):434–444. doi: 10.1097/00000478-198506000-00005. [DOI] [PubMed] [Google Scholar]
  11. DiMaio S. M., Mackay B., Smith J. L., Jr, Dickersin G. R. Neurosarcomatous transformation in malignant melanoma: an ultrastructural study. Cancer. 1982 Dec 1;50(11):2345–2354. doi: 10.1002/1097-0142(19821201)50:11<2345::aid-cncr2820501121>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  12. Erlandson R. A. Melanotic schwannoma of spinal nerve origin. Ultrastruct Pathol. 1985;9(1-2):123–129. doi: 10.3109/01913128509055494. [DOI] [PubMed] [Google Scholar]
  13. Font R. L., Truong L. D. Melanotic schwannoma of soft tissues. Electron-microscopic observations and review of literature. Am J Surg Pathol. 1984 Feb;8(2):129–138. doi: 10.1097/00000478-198402000-00007. [DOI] [PubMed] [Google Scholar]
  14. Fu Y. S., Kaye G. I., Lattes R. Primary malignant melanocytic tumors of the sympathetic ganglia, with an ultrastructural study of one. Cancer. 1975 Dec;36(6):2029–2041. doi: 10.1002/cncr.2820360917. [DOI] [PubMed] [Google Scholar]
  15. Gelfand E. T., Taylor R. F., Hendin D., Akabutu J., Callaghan J. C. Melanotic malignant schwannoma of the right atrium. J Thorac Cardiovasc Surg. 1977 Nov;74(5):808–812. [PubMed] [Google Scholar]
  16. Gould V. E., Linnoila R. I., Memoli V. A., Warren W. H. Neuroendocrine components of the bronchopulmonary tract: hyperplasias, dysplasias, and neoplasms. Lab Invest. 1983 Nov;49(5):519–537. [PubMed] [Google Scholar]
  17. Gould V. E., Memoli V. A., Dardi L. E., Sobel H. J., Somers S. C., Johannessen J. V. Neuroendocrine carcinomas with multiple immunoreactive peptides and melanin production. Ultrastruct Pathol. 1981 Jul-Sep;2(3):199–217. doi: 10.3109/01913128109048304. [DOI] [PubMed] [Google Scholar]
  18. Graham D. I., Paterson A., McQueen A., Milne J. A., Urich H. Melanotic tumours (Blue Naevi) of spinal nerve roots. J Pathol. 1976 Feb;118(2):83–89. doi: 10.1002/path.1711180204. [DOI] [PubMed] [Google Scholar]
  19. Grazer R., Cohen S. M., Jacobs J. B., Lucas P. Melanin-containing peripheral carcinoid of the lung. Am J Surg Pathol. 1982 Jan;6(1):73–78. doi: 10.1097/00000478-198201000-00009. [DOI] [PubMed] [Google Scholar]
  20. HIGASHINO K. I., SATO J. [On a primary malignant melanoma in the posterior mediastinum. A contribution to the knowledge of neural crest tumors]. Sci Rep Res Inst Tohoku Univ Med. 1959 Dec;9:90–100. [PubMed] [Google Scholar]
  21. Janzer R. C., Makek M. Intraoral malignant melanotic schwannoma. Ultrastructural evidence for melanogenesis by Schwann's cells. Arch Pathol Lab Med. 1983 Jun;107(6):298–301. [PubMed] [Google Scholar]
  22. Kemnitz P., Spormann H., Heinrich P. Meningioma of lung: first report with light and electron microscopic findings. Ultrastruct Pathol. 1982 Oct-Dec;3(4):359–365. doi: 10.3109/01913128209018558. [DOI] [PubMed] [Google Scholar]
  23. Krausz T., Azzopardi J. G., Pearse E. Malignant melanoma of the sympathetic chain: with a consideration of pigmented nerve sheath tumours. Histopathology. 1984 Sep;8(5):881–894. doi: 10.1111/j.1365-2559.1984.tb02403.x. [DOI] [PubMed] [Google Scholar]
  24. Lowman R. M., Livolsi V. A. Pigmented (melanotic) schwannomas of the spinal canal. Cancer. 1980 Jul 15;46(2):391–397. doi: 10.1002/1097-0142(19800715)46:2<391::aid-cncr2820460230>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  25. Mandybur T. I. Melanotic nerve sheath tumors. J Neurosurg. 1974 Aug;41(2):187–192. doi: 10.3171/jns.1974.41.2.0187. [DOI] [PubMed] [Google Scholar]
  26. Mennemeyer R. P., Hallman K. O., Hammar S. P., Raisis J. E., Tytus J. S., Bockus D. Melanotic schwannoma. Clinical and ultrastructural studies of three cases with evidence of intracellular melanin synthesis. Am J Surg Pathol. 1979 Feb;3(1):3–10. doi: 10.1097/00000478-197902000-00001. [DOI] [PubMed] [Google Scholar]
  27. Miller R. T., Sarikaya H., Sos A. Melanotic schwannoma of the acoustic nerve. Arch Pathol Lab Med. 1986 Feb;110(2):153–154. [PubMed] [Google Scholar]
  28. Muhrer K. H., Fischer H. P. Primary pulmonary neurilemoma. Thorac Cardiovasc Surg. 1983 Oct;31(5):313–316. doi: 10.1055/s-2007-1022005. [DOI] [PubMed] [Google Scholar]
  29. Robertson A. J., Sinclair D. J., Sutton P. P., Guthrie W. Primary melanocarcinoma of the lower respiratory tract. Thorax. 1980 Feb;35(2):158–159. doi: 10.1136/thx.35.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Roviaro G., Montorsi M., Varoli F., Binda R., Cecchetto A. Primary pulmonary tumours of neurogenic origin. Thorax. 1983 Dec;38(12):942–945. doi: 10.1136/thx.38.12.942. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Sengupta P., Das M. M. Melanotic oesophageal neurofibroma. J Indian Med Assoc. 1982 Oct 1;79(7):101–102. [PubMed] [Google Scholar]
  32. Theodossiou A., Segditsas T. Uber ein intraabdominal gelegenes melanotisches Schwannom. Zentralbl Allg Pathol. 1971;114(2):168–172. [PubMed] [Google Scholar]
  33. Unger P. D., Geller G. A., Anderson P. J. Pulmonary lesions in a patient with neurofibromatosis. Arch Pathol Lab Med. 1984 Aug;108(8):654–657. [PubMed] [Google Scholar]

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