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. 1988 Mar;41(3):314–319. doi: 10.1136/jcp.41.3.314

Immunocytochemical study of the cellular immune response in meningiomas.

M L Rossi 1, F Cruz Sanchez 1, J T Hughes 1, M M Esiri 1, H B Coakham 1
PMCID: PMC1141431  PMID: 3258871

Abstract

Twenty four meningiomas (17 benign and seven "atypical" were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, and HLA DR antigens. All the tumours contained macrophages but these cells were more numerous in the atypical meningiomas. Lymphocytes, almost exclusively of the CD8 subtype, were also present in 70% of benign meningiomas and in all atypical meningiomas and were more abundant in the latter. B lymphocytes were present in minimal numbers in three atypical meningiomas and in one benign meningioma. CD4 positive T lymphocytes were present in small numbers in one benign meningioma and in moderate numbers in one atypical meningioma. HLA DR antigen expression on tumour cells was present in about 60% of both tumour groups. The numbers of macrophages and T and CD8 lymphocytes in meningiomas seem to be related to atypical histological features, and the presence of these cells raises questions about host immune response and the relation of this to prognosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alvarez F., Roda J. M., Pérez Romero M., Morales C., Sarmiento M. A., Blázquez M. G. Malignant and atypical meningiomas: a reappraisal of clinical, histological, and computed tomographic features. Neurosurgery. 1987 May;20(5):688–694. doi: 10.1227/00006123-198705000-00003. [DOI] [PubMed] [Google Scholar]
  2. Brooks W. H., Markesbery W. R., Gupta G. D., Roszman T. L. Relationship of lymphocyte invasion and survival of brain tumor patients. Ann Neurol. 1978 Sep;4(3):219–224. doi: 10.1002/ana.410040305. [DOI] [PubMed] [Google Scholar]
  3. Brooks W. H., Netsky M. G., Normansell D. E., Horwitz D. A. Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor. J Exp Med. 1972 Dec 1;136(6):1631–1647. doi: 10.1084/jem.136.6.1631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fontana A., Fierz W., Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature. 1984 Jan 19;307(5948):273–276. doi: 10.1038/307273a0. [DOI] [PubMed] [Google Scholar]
  5. Kril M. P., Apuzzo M. L. Observations in the study of T-lymphocyte subsets by monoclonal antibodies and flow cytometric analysis in intracranial neoplastic disorders. Clin Neurosurg. 1983;30:125–136. doi: 10.1093/neurosurgery/30.cn_suppl_1.125. [DOI] [PubMed] [Google Scholar]
  6. Lampson L. A., Hickey W. F. Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from "histologically normal" to that showing different levels of glial tumor involvement. J Immunol. 1986 Jun 1;136(11):4054–4062. [PubMed] [Google Scholar]
  7. Levy N. L., Mahaley M. S., Jr, Day E. D. In vitro demonstration of cell-mediated immunity to human brain tumors. Cancer Res. 1972 Mar;32(3):477–482. [PubMed] [Google Scholar]
  8. Levy N. L. Specificity of lymphocyte-mediated cytotoxicity in patients with primary intracranial tumors. J Immunol. 1978 Sep;121(3):903–915. [PubMed] [Google Scholar]
  9. Mahaley M. S., Jr, Brooks W. H., Roszman T. L., Bigner D. D., Dudka L., Richardson S. Immunobiology of primary intracranial tumors. Part 1: studies of the cellular and humoral general immune competence of brain-tumor patients. J Neurosurg. 1977 Apr;46(4):467–476. doi: 10.3171/jns.1977.46.4.0467. [DOI] [PubMed] [Google Scholar]
  10. Morantz R. A., Wood G. W., Foster M., Clark M., Gollahon K. Macrophages in experimental and human brain tumors. Part 2: studies of the macrophage content of human brain tumors. J Neurosurg. 1979 Mar;50(3):305–311. doi: 10.3171/jns.1979.50.3.0305. [DOI] [PubMed] [Google Scholar]
  11. Ridley A., Cavanagh J. B. Lymphocytic infiltration in gliomas: evidence of possible host resistance. Brain. 1971;94(1):117–124. doi: 10.1093/brain/94.1.117. [DOI] [PubMed] [Google Scholar]
  12. Rossi M. L., Hughes J. T., Esiri M. M., Coakham H. B., Brownell D. B. Immunohistological study of mononuclear cell infiltrate in malignant gliomas. Acta Neuropathol. 1987;74(3):269–277. doi: 10.1007/BF00688191. [DOI] [PubMed] [Google Scholar]
  13. Schiffer D., Croveri G., Pautasso C. Frequenza e significato degli infiltrati linfo-plasmacellulari nei gliomi umani. Tumori. 1974 May-Jun;60(3):177–184. doi: 10.1177/030089167406000301. [DOI] [PubMed] [Google Scholar]
  14. Stavrou D., Anzil A. P., Weidenbach W., Rodt H. Immunofluorescence study of lymphocytic infiltration in gliomas. Identification of T-lymphocytes. J Neurol Sci. 1977 Aug;33(1-2):275–282. doi: 10.1016/0022-510x(77)90200-3. [DOI] [PubMed] [Google Scholar]
  15. Takeuchi J., Barnard R. O. Perivascular lymphocytic cuffing in astrocytomas. Acta Neuropathol. 1976;35(3):265–271. [PubMed] [Google Scholar]
  16. Traugott U., Scheinberg L. C., Raine C. S. On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation. J Neuroimmunol. 1985 Apr;8(1):1–14. doi: 10.1016/s0165-5728(85)80043-6. [DOI] [PubMed] [Google Scholar]
  17. Underwood J. C. Lymphoreticular infiltration in human tumours: prognostic and biological implications: a review. Br J Cancer. 1974 Dec;30(6):538–548. doi: 10.1038/bjc.1974.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Volc-Platzer B., Majdic O., Knapp W., Wolff K., Hinterberger W., Lechner K., Stingl G. Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease. J Exp Med. 1984 Jun 1;159(6):1784–1789. doi: 10.1084/jem.159.6.1784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Werdelin O., Shevach E. M. Role of nominal antigen and Ia antigen in the binding of antigen-specific T lymphocytes to macrophages. J Immunol. 1979 Dec;123(6):2779–2784. [PubMed] [Google Scholar]
  20. Wood G. W., Morantz R. A. Immunohistologic evaluation of the lymphoreticular infiltrate of human central nervous system tumors. J Natl Cancer Inst. 1979 Mar;62(3):485–491. doi: 10.1093/jnci/62.3.485. [DOI] [PubMed] [Google Scholar]
  21. Woosley R. E., Mahaley M. S., Jr, Mahaley J. L., Miller G. M., Brooks W. H. Immunobiology of primary intracranial tumors. Part 3: Microcytotoxicity assays of specific immune responses of brain tumor patients. J Neurosurg. 1977 Dec;47(6):871–885. doi: 10.3171/jns.1977.47.6.0871. [DOI] [PubMed] [Google Scholar]
  22. von Hanwehr R. I., Hofman F. M., Taylor C. R., Apuzzo M. L. Mononuclear lymphoid populations infiltrating the microenvironment of primary CNS tumors. Characterization of cell subsets with monoclonal antibodies. J Neurosurg. 1984 Jun;60(6):1138–1147. doi: 10.3171/jns.1984.60.6.1138. [DOI] [PubMed] [Google Scholar]

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