Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1988 Jul;41(7):722–725. doi: 10.1136/jcp.41.7.722

Impairment of cytomegalovirus and host balance in elderly subjects.

M Musiani 1, M Zerbini 1, D Zauli 1, G Cometti 1, M La Placa 1
PMCID: PMC1141576  PMID: 2842379

Abstract

The titres of IgG antibody against "late antigens", "immediate early antigens", and "early antigens" induced by cytomegalovirus (CMV) and IgM antibody against "late antigens" induced by CMV were analysed in 67 geriatric subjects by immunocytochemical techniques. The titres obtained were compared with those of an adult control population. Significantly increased titres of IgG antibody against induced antigens and a significant increase in CMV reactivated infections occurred in the elderly compared with control subjects. These findings indicate that the CMV and host balance in the elderly is disturbed, leading to activation of the CMV latent carrier state that follows primary CMV infection.

Full text

PDF
722

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe T., Morimoto C., Toguchi T., Kiyotaki M., Homma M. The cellular basis of impaired T lymphocyte functions in the elderly. J Am Geriatr Soc. 1980 Jun;28(6):265–271. doi: 10.1111/j.1532-5415.1980.tb00532.x. [DOI] [PubMed] [Google Scholar]
  2. Adam E., Melnick J. L., Probtsfield J. L., Petrie B. L., Burek J., Bailey K. R., McCollum C. H., DeBakey M. E. High levels of cytomegalovirus antibody in patients requiring vascular surgery for atherosclerosis. Lancet. 1987 Aug 8;2(8554):291–293. doi: 10.1016/s0140-6736(87)90888-9. [DOI] [PubMed] [Google Scholar]
  3. Antel J. P., Oger J. J., Dropcho E., Richman D. P., Kuo H. H., Arnason B. G. Reduced T-lymphocyte cell reactivity as a function of human aging. Cell Immunol. 1980 Aug 15;54(1):184–192. doi: 10.1016/0008-8749(80)90200-2. [DOI] [PubMed] [Google Scholar]
  4. Drew W. L., Sweet E. S., Miner R. C., Mocarski E. S. Multiple infections by cytomegalovirus in patients with acquired immunodeficiency syndrome: documentation by Southern blot hybridization. J Infect Dis. 1984 Dec;150(6):952–953. doi: 10.1093/infdis/150.6.952. [DOI] [PubMed] [Google Scholar]
  5. Glaser R., Strain E. C., Tarr K. L., Holliday J. E., Donnerberg R. L., Kiecolt-Glaser J. K. Changes in Epstein-Barr virus antibody titers associated with aging. Proc Soc Exp Biol Med. 1985 Jul;179(3):352–355. doi: 10.3181/00379727-179-42108. [DOI] [PubMed] [Google Scholar]
  6. Henson D., Siegel S. E., Fuccillo D. A., Matthew E., Levine A. S. Cytomegalovirus infections during acute childhood leukemia. J Infect Dis. 1972 Nov;126(5):469–481. doi: 10.1093/infdis/126.5.469. [DOI] [PubMed] [Google Scholar]
  7. Kovacs J. A., Gill V., Swan J. C., Ognibene F., Shelhamer J., Parrillo J. E., Masur H. Prospective evaluation of a monoclonal antibody in diagnosis of Pneumocystis carinii pneumonia. Lancet. 1986 Jul 5;2(8497):1–3. doi: 10.1016/s0140-6736(86)92555-9. [DOI] [PubMed] [Google Scholar]
  8. Linde A., Andersson J., Lundgren G., Wahren B. Subclass reactivity to Epstein-Barr virus capsid antigen in primary and reactivated EBV infections. J Med Virol. 1987 Feb;21(2):109–121. doi: 10.1002/jmv.1890210203. [DOI] [PubMed] [Google Scholar]
  9. Linde G. A., Hammarström L., Persson M. A., Smith C. I., Sundqvist V. A., Wahren B. Virus-specific antibody activity of different subclasses of immunoglobulins G and A in cytomegalovirus infections. Infect Immun. 1983 Oct;42(1):237–244. doi: 10.1128/iai.42.1.237-244.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Murasko D. M., Nelson B. J., Silver R., Matour D., Kaye D. Immunologic response in an elderly population with a mean age of 85. Am J Med. 1986 Oct;81(4):612–618. doi: 10.1016/0002-9343(86)90546-2. [DOI] [PubMed] [Google Scholar]
  11. Musiani M., Zerbini M., Carpi C., Plazzi M., Sermasi G., Belletti D., Sacchi R. Serological screening for the prevention of transfusion-acquired cytomegalovirus infection. J Infect. 1984 Sep;9(2):148–152. doi: 10.1016/s0163-4453(84)91078-8. [DOI] [PubMed] [Google Scholar]
  12. Musiani M., Zerbini M., Ferri S., Plazzi M., Gentilomi G., La Placa M. Comparison of the immune response to Epstein-Barr virus and cytomegalovirus in sera and synovial fluids of patients with rheumatoid arthritis. Ann Rheum Dis. 1987 Nov;46(11):837–842. doi: 10.1136/ard.46.11.837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Musiani M., Zerbini M., La Placa M. Alkaline phosphatase immunoenzymatic staining for detection of antigens induced by cytomegalovirus. J Clin Pathol. 1985 Oct;38(10):1155–1157. doi: 10.1136/jcp.38.10.1155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Musiani M., Zerbini M., La Placa M. Rapid diagnosis of viral infections by an alkaline phosphatase immunocytochemical method. J Immunol Methods. 1986 Apr 17;88(2):255–258. doi: 10.1016/0022-1759(86)90013-x. [DOI] [PubMed] [Google Scholar]
  15. Zerbini M., Musiani M., Gentilomi G., La Placa M. Detection of specific immunoglobulin M antibodies to cytomegalovirus by using monoclonal antibody to immunoglobulin M in an indirect immunofluorescence assay. J Clin Microbiol. 1986 Jul;24(1):166–168. doi: 10.1128/jcm.24.1.166-168.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES