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. 1988 Oct;41(10):1089–1092. doi: 10.1136/jcp.41.10.1089

Urinary excretion of albumin and retinol-binding protein during normal pregnancy.

R Beetham 1, A Dawnay 1, M Menabawy 1, A Silver 1
PMCID: PMC1141693  PMID: 3192731

Abstract

In a cross sectional study of 88 pregnant women urinary excretion of albumin, when expressed as a ratio to creatinine concentration, was not significantly different from that in a non-pregnant control group of similar age (p greater than 0.05) and did not change significantly during pregnancy. Only when albumin excretion was expressed as a fractional clearance was the urinary excretion significantly increased in the third trimester compared with the first trimester (p less than 0.05), although it was still not significantly different from that in the non-pregnant control group. Excretion of retinol-binding protein was significantly increased during all three trimesters of pregnancy (p less than 0.01 in each case) and more so in the second and third trimesters than in the first. It is concluded that the increased total protein excretion that has been described during pregnancy is not explained by an increased excretion of albumin which remains essentially normal. In contrast, the tubular absorption of proteins is decreased.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beetham R., Dawnay A., Landon J., Cattell W. R. A radioimmunoassay for retinol-binding protein in serum and urine. Clin Chem. 1985 Aug;31(8):1364–1367. [PubMed] [Google Scholar]
  2. Clark P. M., Evans S. E., Weaver J. B., Flora P. S., Hughes S. H., Whitehead T. P. The investigation of proteinuria in pregnancy using iso-dalt analysis. Br J Obstet Gynaecol. 1984 Oct;91(10):979–985. doi: 10.1111/j.1471-0528.1984.tb03674.x. [DOI] [PubMed] [Google Scholar]
  3. Davison J. M. The effect of pregnancy on kidney function in renal allograft recipients. Kidney Int. 1985 Jan;27(1):74–79. doi: 10.1038/ki.1985.12. [DOI] [PubMed] [Google Scholar]
  4. Dawnay A. B., Thornley C., Cattell W. R. An improved radioimmunoassay for urinary Tamm-Horsfall glycoprotein. Investigation and resolution of factors affecting its quantification. Biochem J. 1982 Sep 15;206(3):461–465. doi: 10.1042/bj2060461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fex G., Felding P. Factors affecting the concentration of free holo retinol-binding protein in human plasma. Eur J Clin Invest. 1984 Apr;14(2):146–149. doi: 10.1111/j.1365-2362.1984.tb02104.x. [DOI] [PubMed] [Google Scholar]
  6. Gerö G., Anthony F., Rowe D. J., Dennis K. J. Increased urinary excretion of retinol-binding protein during normal pregnancies. Clin Chem. 1986 May;32(5):916–917. [PubMed] [Google Scholar]
  7. Irgens-Møller L., Hemmingsen L., Holm J. Diagnostic value of microalbuminuria in pre-eclampsia. Clin Chim Acta. 1986 Jun 30;157(3):295–298. doi: 10.1016/0009-8981(86)90304-9. [DOI] [PubMed] [Google Scholar]
  8. Kaltenbach F. J., Boesken W. H., Wilhelm C., Ziupa J., Toussaint M. N., Quaas L. Urinary protein patterns and preeclampsia. Clin Exp Hypertens B. 1983;2(1):133–144. doi: 10.3109/10641958309023466. [DOI] [PubMed] [Google Scholar]
  9. Kelly A. M., McEwan H. P. Aetiology and effects of proteinuria in pregnancy. Contrib Nephrol. 1981;24:134–138. doi: 10.1159/000395238. [DOI] [PubMed] [Google Scholar]
  10. Lopez-Espinoza I., Dhar H., Humphreys S., Redman C. W. Urinary albumin excretion in pregnancy. Br J Obstet Gynaecol. 1986 Feb;93(2):176–181. doi: 10.1111/j.1471-0528.1986.tb07883.x. [DOI] [PubMed] [Google Scholar]
  11. Silver A., Dawnay A., Landon J., Cattell W. R. Immunoassays for low concentrations of albumin in urine. Clin Chem. 1986 Jul;32(7):1303–1306. [PubMed] [Google Scholar]
  12. Simanowitz M. D., MacGregor W. G., Hobbs J. R. Proteinuria in pre-eclampsia. J Obstet Gynaecol Br Commonw. 1973 Feb;80(2):103–108. doi: 10.1111/j.1471-0528.1973.tb02162.x. [DOI] [PubMed] [Google Scholar]
  13. Viberti G. C. Early functional and morphological changes in diabetic nephropathy. Clin Nephrol. 1979 Aug;12(2):47–53. [PubMed] [Google Scholar]
  14. WEARING M. P. Protein in the urine during pregnancy; a simple quantitative method of estimation. Obstet Gynecol. 1957 May;9(5):549–553. [PubMed] [Google Scholar]
  15. Wright A., Steele P., Bennett J. R., Watts G., Polak A. The urinary excretion of albumin in normal pregnancy. Br J Obstet Gynaecol. 1987 May;94(5):408–412. doi: 10.1111/j.1471-0528.1987.tb03117.x. [DOI] [PubMed] [Google Scholar]

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