Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1988 Oct;41(10):1117–1119. doi: 10.1136/jcp.41.10.1117

Lactoferrin in aspirates of odontogenic cyst fluid.

A J Smith 1, J B Matthews 1, G I Mason 1, R M Browne 1
PMCID: PMC1141699  PMID: 3192735

Abstract

The possibility that the presence of lactoferrin in aspirates of odontogenic cyst fluid might be a useful preoperative diagnostic marker for odontogenic keratocyst was investigated. Using qualitative and quantitative immunodiffusion methods fluid from 29 of 29 dental (radicular) cysts, 12 of 14 dentigerous cysts and 27 of 31 keratocysts were found to contain lactoferrin. Although some of the highest concentrations of lactoferrin were detected in fluids from keratocysts, there was no significant difference between lactoferrin concentrations among the three groups. Neutrophil elastase was detected in 20 of 24 samples tested, 22 of which also contained lactoferrin. Immunocytochemical localisation of both lactoferrin and elastase was confined to neutrophils infiltrating cyst walls. These results suggest that lactoferrin in fluid from odontogenic cysts is derived from infiltrating neutrophils and that its presence in aspirated fluids is not a useful diagnostic marker for odontogenic keratocyst.

Full text

PDF
1117

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blackshaw A. J., Levison D. A. Eosinophilic infiltrates of the gastrointestinal tract. J Clin Pathol. 1986 Jan;39(1):1–7. doi: 10.1136/jcp.39.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Browne R. M. Some observations on the fluids of odontogenic cysts. J Oral Pathol. 1976 Mar;5(2):74–87. doi: 10.1111/j.1600-0714.1976.tb01869.x. [DOI] [PubMed] [Google Scholar]
  3. Browne R. M. The pathogenesis of odontogenic cysts: a review. J Oral Pathol. 1975 Jul;4(1):31–46. doi: 10.1111/j.1600-0714.1975.tb01738.x. [DOI] [PubMed] [Google Scholar]
  4. Cohen M. A. Pathways of inflammatory cellular exudate through radicular cyst epithelium: a light and scanning electron microscope study. J Oral Pathol. 1979 Dec;8(6):369–378. doi: 10.1111/j.1600-0714.1979.tb01840.x. [DOI] [PubMed] [Google Scholar]
  5. Douglas C. W., Craig G. T. Evidence for the presence of lactoferrin in odontogenic keratocyst fluids. J Clin Pathol. 1987 Aug;40(8):914–921. doi: 10.1136/jcp.40.8.914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Doumas B. T., Watson W. A., Biggs H. G. Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta. 1971 Jan;31(1):87–96. doi: 10.1016/0009-8981(71)90365-2. [DOI] [PubMed] [Google Scholar]
  7. Goldenberg H., Drewes P. A. Direct photometric determination of globulin in serum. Clin Chem. 1971 May;17(5):358–362. [PubMed] [Google Scholar]
  8. Kramer I. R., Toller P. A. The use of exfoliative cytology and protein estimations in preoperative diagnosis of odontogenic keratocysts. Int J Oral Surg. 1973;2(4):143–151. doi: 10.1016/s0300-9785(73)80031-6. [DOI] [PubMed] [Google Scholar]
  9. Kuusela P., Hormia M., Tuompo H., Ylipaavalniemi P. Demonstration and partial characterization of a novel soluble antigen present in keratocysts. Oncodev Biol Med. 1982;3(4):283–290. [PubMed] [Google Scholar]
  10. Kuusela P., Ylipaavalniemi P., Thesleff I. The relationship between the keratocyst antigen (KCA) and keratin. J Oral Pathol. 1986 May;15(5):287–291. doi: 10.1111/j.1600-0714.1986.tb00626.x. [DOI] [PubMed] [Google Scholar]
  11. Matthews J. B., Browne R. M. An immunocytochemical study of the inflammatory cell infiltrate and epithelial expression of HLA-DR in odontogenic cysts. J Oral Pathol. 1987 Mar;16(3):112–117. doi: 10.1111/j.1600-0714.1987.tb01476.x. [DOI] [PubMed] [Google Scholar]
  12. Matthews J. B., Mason G. I. Influence of decalcifying agents on immunoreactivity of formalin-fixed, paraffin-embedded tissue. Histochem J. 1984 Jul;16(7):771–787. doi: 10.1007/BF01095281. [DOI] [PubMed] [Google Scholar]
  13. Smith A. J., Browne R. M. Analysis of odontogenic keratocyst fluids for preoperative diagnosis. J Clin Pathol. 1987 Mar;40(3):354–355. doi: 10.1136/jcp.40.3.354-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Southgate J., Whicher J. T., Davies J. D., O'Reilly D. S., Matthews R. W. A protein of squamous keratinising epithelium from odontogenic keratocyst fluid. Virchows Arch A Pathol Anat Histopathol. 1986;409(5):705–713. doi: 10.1007/BF00713435. [DOI] [PubMed] [Google Scholar]
  15. Toller P. A. Protein substances in odontogenic cyst fluids. Br Dent J. 1970 Apr 7;128(7):317–322. doi: 10.1038/sj.bdj.4802465. [DOI] [PubMed] [Google Scholar]
  16. Toller P. A. The osmolality of fluids from cysts of the jaws. Br Dent J. 1970 Sep 15;129(6):275–278. doi: 10.1038/sj.bdj.4802570. [DOI] [PubMed] [Google Scholar]
  17. Toller P. Permeability of cyst walls in vivo: investigations with radioactive tracers. Proc R Soc Med. 1966 Aug;59(8):724–729. doi: 10.1177/003591576605900821. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES