Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1989 Jan;42(1):63–68. doi: 10.1136/jcp.42.1.63

Acute phase response in cerebral infarction.

J Syrjänen 1, A M Teppo 1, V V Valtonen 1, M Iivanainen 1, C P Maury 1
PMCID: PMC1141793  PMID: 2493489

Abstract

The serum concentrations of the acute phase proteins, C-reactive protein, serum amyloid A protein, and alpha-1-antichymotrypsin were determined in 50 young and middle aged patients with cerebral infarction and in sex and age matched community controls. Of 46 case control pairs, 11 cases but only one control had raised acute phase protein concentrations simultaneously (p less than 0.01); four case control pairs were excluded because of an infectious complication following infarction and an acute phase response. Seven of the 11 patients (64%) with raised acute phase protein concentrations had a history of bacterial infection in the preceding month but of the remaining 35 patients without raised concentrations only four (11%) had such a history (p less than 0.01). In general, the acute phase response was less pronounced and occurred less often than has been reported in patients after acute myocardial infarction. The results suggest that a positive acute phase response is associated with a preceding bacterial infection or with an infectious complication after cerebral infarction. Measurement of acute phase proteins, therefore, could be used to evaluate the possible role of preceding bacterial infection in the development of cerebral infarction and also in the management of these patients as an early indicator of possible infectious complications.

Full text

PDF
63

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cooper E. H., Forbes M. A., Hambling M. H. Serum beta 2-microglobulin and C reactive protein concentrations in viral infections. J Clin Pathol. 1984 Oct;37(10):1140–1143. doi: 10.1136/jcp.37.10.1140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Fiedel B. A. Platelet agonist synergism by the acute phase reactant C-reactive protein. Blood. 1985 Feb;65(2):264–269. [PubMed] [Google Scholar]
  3. Kerttula Y., Leinonen M., Koskela M., Mäkelä P. H. The aetiology of pneumonia. Application of bacterial serology and basic laboratory methods. J Infect. 1987 Jan;14(1):21–30. doi: 10.1016/s0163-4453(87)90730-4. [DOI] [PubMed] [Google Scholar]
  4. Marhaug G., Hårklau L., Olsen B., Husby G., Husebekk A., Wang H. Serum amyloid A protein in acute myocardial infarction. Acta Med Scand. 1986;220(4):303–306. doi: 10.1111/j.0954-6820.1986.tb02769.x. [DOI] [PubMed] [Google Scholar]
  5. Maury C. P. Comparative study of serum amyloid A protein and C-reactive protein in disease. Clin Sci (Lond) 1985 Feb;68(2):233–238. doi: 10.1042/cs0680233. [DOI] [PubMed] [Google Scholar]
  6. Maury C. P., Teppo A. M. Comparative study of serum amyloid-related protein SAA, C-reactive protein, and beta 2-microglobulin as markers of renal allograft rejection. Clin Nephrol. 1984 Dec;22(6):284–292. [PubMed] [Google Scholar]
  7. McCarthy P. L., Frank A. L., Ablow R. C., Masters S. J., Dolan T. F., Jr Value of the C-reactive protein test in the differentiation of bacterial and viral pneumonia. J Pediatr. 1978 Mar;92(3):454–456. doi: 10.1016/s0022-3476(78)80448-x. [DOI] [PubMed] [Google Scholar]
  8. Peltola H. O. C-reactive protein for rapid monitoring of infections of the central nervous system. Lancet. 1982 May 1;1(8279):980–982. doi: 10.1016/s0140-6736(82)91989-4. [DOI] [PubMed] [Google Scholar]
  9. Pepys M. B., Baltz M. L. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv Immunol. 1983;34:141–212. doi: 10.1016/s0065-2776(08)60379-x. [DOI] [PubMed] [Google Scholar]
  10. Putto A., Ruuskanen O., Meurman O., Ekblad H., Korvenranta H., Mertsola J., Peltola H., Sarkkinen H., Viljanen M. K., Halonen P. C reactive protein in the evaluation of febrile illness. Arch Dis Child. 1986 Jan;61(1):24–29. doi: 10.1136/adc.61.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shainkin-Kestenbaum R., Winikoff Y., Cristal N. Serum amyloid A concentrations during the course of acute ischaemic heart disease. J Clin Pathol. 1986 Jun;39(6):635–637. doi: 10.1136/jcp.39.6.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Smith S. J., Bos G., Esseveld M. R., Van Eijk H. G., Gerbrandy J. Acute-phase proteins from the liver and enzymes from myocardial infarction; a quantitative relationship. Clin Chim Acta. 1977 Nov 15;81(1):75–85. doi: 10.1016/0009-8981(77)90415-6. [DOI] [PubMed] [Google Scholar]
  13. Smith T. New year message. Br Med J (Clin Res Ed) 1988 Jan 2;296(6614):1–2. doi: 10.1136/bmj.296.6614.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Whicher J. T., Chambers R. E., Higginson J., Nashef L., Higgins P. G. Acute phase response of serum amyloid A protein and C reactive protein to the common cold and influenza. J Clin Pathol. 1985 Mar;38(3):312–316. doi: 10.1136/jcp.38.3.312. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES