Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1989 Apr;42(4):398–402. doi: 10.1136/jcp.42.4.398

Aberrant phenotypes in peripheral T cell lymphomas.

N Hastrup 1, E Ralfkiaer 1, G Pallesen 1
PMCID: PMC1141912  PMID: 2469701

Abstract

Seventy six peripheral T cell lymphomas were examined immunohistologically to test their reactivity with a panel of monoclonal antibodies against 11 T cell associated antigens (CD1-8, CD27, UCHL1, and the T cell antigen receptor). Sixty two (82%) lymphomas showed aberrant phenotypes, and four main categories were distinguished as follows: (i) lack of one or several pan-T cell antigens (49, 64% of the cases); (ii) loss of both the CD4 and CD8 antigens (11, 15% of the cases); (iii) coexpression of the CD4 and CD8 antigens (13, 17% of the cases); and (iv) expression of the CD1 antigen (eight, 11% of the cases). No correlation was seen between the occurrence of aberrant phenotypes and the histological subtype. It is concluded that the demonstration of an aberrant phenotype is a valuable supplement to histological assessment in the diagnosis of peripheral T cell lymphomas. It is recommended that the panel of monoclonal antibodies against T cell differentiation antigens should be fairly large, as apparently any antigen may be lost in the process of malignant transformation.

Full text

PDF
398

Images in this article

400Figure
on p.400

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borowitz M. J., Reichert T. A., Brynes R. K., Cousar J. B., Whitcomb C. C., Collins R. D., Crissman J. D., Byrne G. E., Jr The phenotypic diversity of peripheral T-cell lymphomas: the Southeastern Cancer Study Group experience. Hum Pathol. 1986 Jun;17(6):567–574. doi: 10.1016/s0046-8177(86)80128-9. [DOI] [PubMed] [Google Scholar]
  2. Cordell J. L., Falini B., Erber W. N., Ghosh A. K., Abdulaziz Z., MacDonald S., Pulford K. A., Stein H., Mason D. Y. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984 Feb;32(2):219–229. doi: 10.1177/32.2.6198355. [DOI] [PubMed] [Google Scholar]
  3. Doggett R. S., Wood G. S., Horning S., Levy R., Dorfman R. F., Bindl J., Warnke R. A. The immunologic characterization of 95 nodal and extranodal diffuse large cell lymphomas in 89 patients. Am J Pathol. 1984 May;115(2):245–252. [PMC free article] [PubMed] [Google Scholar]
  4. Geisler C., Plesner T., Pallesen G., Skjødt K., Odum N., Larsen J. K. Characterization and expression of the human T cell receptor-T3 complex by monoclonal antibody F101.01. Scand J Immunol. 1988 Jun;27(6):685–696. doi: 10.1111/j.1365-3083.1988.tb02402.x. [DOI] [PubMed] [Google Scholar]
  5. Grogan T. M., Fielder K., Rangel C., Jolley C. J., Wirt D. P., Hicks M. J., Miller T. P., Brooks R., Greenberg B., Jones S. Peripheral T-cell lymphoma: aggressive disease with heterogeneous immunotypes. Am J Clin Pathol. 1985 Mar;83(3):279–288. doi: 10.1093/ajcp/83.3.279. [DOI] [PubMed] [Google Scholar]
  6. Jack A. S., Lee F. D. Morphological and immunohistochemical characteristics of T-cell malignant lymphomas in the west of Scotland. Histopathology. 1986 Mar;10(3):223–234. doi: 10.1111/j.1365-2559.1986.tb02477.x. [DOI] [PubMed] [Google Scholar]
  7. Lanier L. L., Weiss A. Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus. Nature. 1986 Nov 20;324(6094):268–270. doi: 10.1038/324268a0. [DOI] [PubMed] [Google Scholar]
  8. Nasu K., Said J., Vonderheid E., Olerud J., Sako D., Kadin M. Immunopathology of cutaneous T-cell lymphomas. Am J Pathol. 1985 Jun;119(3):436–447. [PMC free article] [PubMed] [Google Scholar]
  9. Norton A. J., Ramsay A. D., Smith S. H., Beverley P. C., Isaacson P. G. Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues. J Clin Pathol. 1986 Apr;39(4):399–405. doi: 10.1136/jcp.39.4.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Picker L. J., Brenner M. B., Weiss L. M., Smith S. D., Warnke R. A. Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas. Am J Pathol. 1987 Dec;129(3):434–440. [PMC free article] [PubMed] [Google Scholar]
  11. Picker L. J., Weiss L. M., Medeiros L. J., Wood G. S., Warnke R. A. Immunophenotypic criteria for the diagnosis of non-Hodgkin's lymphoma. Am J Pathol. 1987 Jul;128(1):181–201. [PMC free article] [PubMed] [Google Scholar]
  12. Ralfkiaer E., Wantzin G. L., Mason D. Y., Hou-Jensen K., Stein H., Thomsen K. Phenotypic characterization of lymphocyte subsets in mycosis fungoides. Comparison with large plaque parapsoriasis and benign chronic dermatoses. Am J Clin Pathol. 1985 Nov;84(5):610–619. doi: 10.1093/ajcp/84.5.610. [DOI] [PubMed] [Google Scholar]
  13. Suchi T., Lennert K., Tu L. Y., Kikuchi M., Sato E., Stansfeld A. G., Feller A. C. Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification. J Clin Pathol. 1987 Sep;40(9):995–1015. doi: 10.1136/jcp.40.9.995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Weiss L. M., Crabtree G. S., Rouse R. V., Warnke R. A. Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Am J Pathol. 1985 Feb;118(2):316–324. [PMC free article] [PubMed] [Google Scholar]
  15. Wood G. S., Burke J. S., Horning S., Doggett R. S., Levy R., Warnke R. A. The immunologic and clinicopathologic heterogeneity of cutaneous lymphomas other than mycosis fungoides. Blood. 1983 Aug;62(2):464–472. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES