Abstract
A child with disseminated Ewing's sarcoma underwent cytogenetic investigations which showed different structural rearrangements of chromosome 22 at diagnosis (?ring22), and at relapse [t(10;22)], but the classic translocation t(11;22) was not detectable. This case provides further evidence of the importance of chromosome 22 in this disease, while raising some questions about the central importance of the translocation between chromosomes 11 and 22.
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- Aurias A., Rimbaut C., Buffe D., Zucker J. M., Mazabraud A. Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors. Cancer Genet Cytogenet. 1984 May;12(1):21–25. doi: 10.1016/0165-4608(84)90003-7. [DOI] [PubMed] [Google Scholar]
- Bennett D. D., Garvin A. J., Killough B. W., Stanley W. S. Isochromosome 11q in a case of Ewing's sarcoma. Cancer Genet Cytogenet. 1987 Mar;25(1):97–101. doi: 10.1016/0165-4608(87)90164-6. [DOI] [PubMed] [Google Scholar]
- Emanuel B. S., Nowell P. C., McKeon C., Croce C. M., Israel M. A. Translocation breakpoint mapping: molecular and cytogenetic studies of chromosome 22. Cancer Genet Cytogenet. 1986 Jan 1;19(1-2):81–92. doi: 10.1016/0165-4608(86)90375-4. [DOI] [PubMed] [Google Scholar]
- Turc-Carel C., Philip I., Berger M. P., Philip T., Lenoir G. M. Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12). Cancer Genet Cytogenet. 1984 May;12(1):1–19. doi: 10.1016/0165-4608(84)90002-5. [DOI] [PubMed] [Google Scholar]
- Whang-Peng J., Triche T. J., Knutsen T., Miser J., Kao-Shan S., Tsai S., Israel M. A. Cytogenetic characterization of selected small round cell tumors of childhood. Cancer Genet Cytogenet. 1986 Apr 1;21(3):185–208. doi: 10.1016/0165-4608(86)90001-4. [DOI] [PubMed] [Google Scholar]