Table 1.
(a) Patient demographics for healthy control subjects. (b) Patient demographics for subjects with hepatocellular carcinoma (HCC).
| (a) | |||
| Total (n = 96) | |||
| Average Age | 50.38 | ||
| Male Sex | 44 | ||
| Race | |||
| White | 32 (72.72%) | ||
| Black | 11 (25.0%) | ||
| Asian | 1 (2.27%) | ||
| Average BMI (kg/m2) | 28.06 | ||
| Female Sex | 50 | ||
| Race | |||
| White | 45 (90.0%) | ||
| Black | 5 (10.0%) | ||
| Average BMI (kg/m2) | 27.46 | ||
| (b) | |||
| Total HCC (n = 41) | HCC + Cirrhosis (n = 25) | HCC Alone (n = 16) | |
| Median Age (IQR) | 68 (62.5–76.5) | 66 (62–72) | 73 (62.5–79.3) |
| Male Sex | 13 | 7 (28%) | 6 (37.5%) |
| Race | |||
| White | 34 (82.9%) | 19 (76%) | 15 (93.7%) |
| Black | 4 (9.8%) | 4 (16%) | - |
| Asian | 3 (7.3%) | 2 (8%) | 1 (6.3%) |
| BMI (kg/m2) | 27.3 (24–30.7) | 27.3 (24–31.3) | 27.6 (25.7–30.7) |
| Etiology of Cirrhosis | - | ||
| NASH | 4 (9.8%) | 4 (16%) | |
| Hepatitis B | 4 (9.8%) | 4 (16%) | |
| Hepatitis C | 14 (34.1%) | 14 (56%) | |
| Idiopathic | 2 (4.9%) | 2 (8%) | |
| Hemochromatosis | 1 (2.4%) | 1 (4%) | |
| Diabetes | 11 (26.8%) | 8 (32%) | 3 (18.8%) |
|
No. Lesions Median (IQR) |
1 (1–2) | 1 (1–2) | 1 (1–3) |
|
Size Largest Lesion Median cm (IQR) |
4 (2.5–6) | 3 (2–4) | 10 (4.3–14.3) |
| Treatment Pre-Sample Collection | |||
| Y90 | 3 (7.3%) | 2 (8%) | 1 (6.3%) |
| TACE | 4 (9.8%) | 2 (8%) | 2 (12.6%) |
| None | 34 (82.9%) | 21 (84%) | 13 (81.1%) |
| Grade of Differentiation | |||
| Well | 4 (9.8%) | - | 4 (25%) |
| Moderate | 34 (82.9%) | 24 (96%) | 10 (62.5%) |
| Poor | 3 (7.3%) | 1 (4%) | 2 (12.6%) |
| Vascular Invasion | 30 (73.2%) | 20 (80%) | 10 (62.5%) |
| Recurrence | 15 (36.6%) | 9 (36%) | 6 (37.5%) |
Age, race and BMI are expressed as count in percent; gut microbe-associated metabolites are altered in HCC patients compared to healthy controls. All the variables are expressed as count in percent. Age, number and size of lesions is presented as median (IQR).