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. 1982 Apr 1;69(4):212–214. doi: 10.1002/bjs.1800690414

Nerve growth factor potentiates stress-induced gastric ulceration

Arthur K C Li 1,2,✉, Mary Jo Koroly 3,4, B W Jeppsson 5,6, M E Schattenkerk 7,8, Michael Young 9,10, Ronald A Malt 11,12
PMCID: PMC11429151  PMID: 7074319

Abstract

Increased salivary flow stimulated by intravenous isoproterenol (IPR) (6 mg/kg) doubled the incidence of gastric stress ulceration in normal male mice, but not after submandibular sialadenectomy. The submandibular salivary glands in these mice secrete large amounts of several growth factors, including epidermal growth factor (EGF) and nerve growth factor (NGF). Intragastric instillation of a quantity of high molecular weight NGF equimolar to that in IPR-stimulated saliva doubled the incidence of stress ulcers after submandibular sialadenectomy. This action of NGF in vivo is not mediated by its nerve growth promoting properties nor its plasminogen activating property.

Contributor Information

Arthur K C Li, The Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, the Laboratory of Physical Biochemistry, Massachusetts General Hospital, Boston, Massachusetts, USA; Departments of Surgery, Anatomy and Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Mary Jo Koroly, The Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, the Laboratory of Physical Biochemistry, Massachusetts General Hospital, Boston, Massachusetts, USA; Departments of Surgery, Anatomy and Medicine, Harvard Medical School, Boston, Massachusetts, USA.

B W Jeppsson, The Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, the Laboratory of Physical Biochemistry, Massachusetts General Hospital, Boston, Massachusetts, USA; Departments of Surgery, Anatomy and Medicine, Harvard Medical School, Boston, Massachusetts, USA.

M E Schattenkerk, The Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, the Laboratory of Physical Biochemistry, Massachusetts General Hospital, Boston, Massachusetts, USA; Departments of Surgery, Anatomy and Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Michael Young, The Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, the Laboratory of Physical Biochemistry, Massachusetts General Hospital, Boston, Massachusetts, USA; Departments of Surgery, Anatomy and Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Ronald A Malt, The Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, the Laboratory of Physical Biochemistry, Massachusetts General Hospital, Boston, Massachusetts, USA; Departments of Surgery, Anatomy and Medicine, Harvard Medical School, Boston, Massachusetts, USA.

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Articles from The British Journal of Surgery are provided here courtesy of Oxford University Press

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