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[Preprint]. 2024 Sep 20:2024.09.13.612899. [Version 2] doi: 10.1101/2024.09.13.612899

Muscle spindles provide flexible sensory feedback for movement sequences

William P Olson, Varun B Chokshi, Jeong Jun Kim, Noah Cowan, Daniel H O’Connor
PMCID: PMC11429703  PMID: 39345532

Abstract

Sensory feedback is essential for motor performance and must adapt to task demands. Muscle spindle afferents (MSAs) are a major primary source of feedback about movement, and their responses are readily modulated online by gain-controller fusimotor neurons and other mechanisms. They are therefore a powerful site for implementing flexible sensorimotor control. We recorded from MSAs innervating the jaw musculature during performance of a directed lick sequence task. Jaw MSAs encoded complex jaw–tongue kinematics. However, kinematic encoding alone accounted for less than half of MSA spiking variability. MSA representations of kinematics changed based on sequence progression (beginning, middle, or end of the sequence, or reward consumption), suggesting that MSAs are flexibly tuned across the task. Dynamic control of incoming feedback signals from MSAs may be a strategy for adaptable sensorimotor control during performance of complex behaviors.

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