Table 1.
Drugs and the types of C–C bond cleavage.
| Drug Name | Indications | C–C Bond Cleavage Type |
|---|---|---|
| Plitidepsin | Antitumor and antiviral activities | C(sp3)-C(sp3) [30,31,32,33] |
| IKRO-105714 | Alleviate atopic dermatitis | C(sp3)-C(sp3) [34,35] |
| Noscapine | Cough suppressing | C(sp3)-C(sp3) [36] |
| Tipranavir | Anti-HIV agent | C(sp3)-C(sp3) [37,38] |
| Evatanepag | Treats tibial fractures. | C(sp3)-C(sp3) [39] |
| Olanexidine | Antiseptic agent | C(sp3)-C(sp3) [40,41] |
| Nabumetone | Treats pain and arthritis | C(sp3)-C(sp3) [42,43,44,45] |
| Pexidartinib | Treats tenosynovial giant cell tumor | C(sp2)-C(sp3) [46] |
| Nefazodone | Treats depression | C(sp2)-C(sp3) [47] |
| Indacaterol | Treats chronic obstructive pulmonary disease and asthma | C(sp2)-C(sp3) [48] |
| DPC 963 | Anti-HIV agent | Ring-open [49,50] |
| Tetramethylpiperidine | Building blocks of drugs | Ring-open [51,52,53] |
| Cipargamin | Anti-Malarial | Ring-open [54,55] |