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. 1984 Aug 1;221(3):915–917. doi: 10.1042/bj2210915

Effects of an adenosine-receptor antagonist on insulin-resistance in soleus muscle from obese Zucker rats.

R A Challis, L Budohoski, B McManus, E A Newsholme
PMCID: PMC1144125  PMID: 6383352

Abstract

The decreased sensitivity of glycolysis to insulin seen in isolated soleus muscles from genetically obese Zucker rats was abolished by addition of the adenosine-receptor antagonist 8-phenyltheophylline to the incubation medium; 8-phenyltheophylline had no effect on the sensitivity of glycogen synthesis to insulin. These findings suggest that changes in the sensitivity of glucose utilization by muscles of genetically obese rats may be explained, in part, by a modification in either the concentration of adenosine or the affinity of adenosine receptors in skeletal muscle.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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