Table 3. Summary of studies included in this article.

CoQ10: coenzyme Q10, RCT: randomized controlled trial, CPK: creatine phosphokinase, SAMS: statin-associated muscular symptoms, HDL: high-density lipoprotein

Author, title, and year of publication	Study design	Group sample size	Intervention studied	Result	Conclusion
Qu et al. (2018); Effects of coenzyme Q10 on statin-induced myopathy: an updated meta-analysis of randomized controlled trial [22]	Meta-analysis of RCTs	575	To assess the effect of CoQ10 supplementation on statin-induced myopathy	294 statin users with statin-induced muscular symptoms were given CoQ10 supplements and 281 of the total patients were enrolled in a placebo group and their muscular symptoms were assessed. The treatment group showed significant improvement without any side effects	CoQ10 reduces statin-induced myopathy significantly
Derosa et al. (2019); Coenzyme Q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study randomized controlled trial [23]	RCT	60	Effect of CoQ10 supplementation of 100 mg with reduced statin dose on statin-induced myopathy	The Clinical Index Score for myalgia was improved after 3 months with CoQ10, while no change was observed in the placebo	The supplementation of CoQ10 with half dosage statin in previously statin-intolerant patients improves clinical symptoms such as myalgia or pain
Skarlovnik et al. (2014): Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study [24]	RCT	50	Effect of CoQ10 supplementation 50 mg twice daily on statin-induced muscular complaints	25 patients were given 50 mg CoQ10 twice daily and 25 patients were given a placebo tablet and both groups were assessed after 30 days. Pain severity score and pain interference score improved in the treatment group	CoQ10 helps ameliorate statin-induced muscular complaints
Yasser et al. (2021); Assessment of some clinical and biochemical parameters after combining coenzyme Q10 to statin in dyslipidemic patients [25]	RCT	52	CoQ10 200 mg was given to patients in the treatment group along with the atorvastatin vs placebo group in which only atorvastatin was given, and the effect was observed after 12 weeks for CPK, lipid peroxidation, SAMS, lipid profile, liver enzymes, and metabolic parameters were assessed	Patients in the treatment group showed improvement in muscular symptoms as well as raised serum CoQ10 levels along with a reduction in CPK and lipid peroxidation while improving HDL levels	Signify the role of CoQ10 as a potential treatment of statin-induced myopathy
Zlatohlavek et al. (2012): The effect of coenzyme Q10 in statin myopathy [26]	RCT	28	To study the effect of CoQ10 supplementation in reducing statin-associated myopathy	28 patients were given statins of various doses and types, and when they reported muscular complaints. CoQ10 supplement was given. They were then assessed over a period of 3 to 6 months and it was established that CoQ10 is effective in reducing muscular complaints	CoQ10 is effective in statin-induced myopathy with side effects