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. 1984 Sep 1;222(2):463–466. doi: 10.1042/bj2220463

Antioxidative effect of ubiquinones on mitochondrial membranes.

L Landi, L Cabrini, A M Sechi, P Pasquali
PMCID: PMC1144200  PMID: 6477527

Abstract

Peroxidation of mitochondria occurs extensively in ubiquinone-depleted membranes. Reincorporation into the membranes of either the physiological ubiquinone or a short-chain homologue protects mitochondria against peroxidation. The ability to prevent this phenomenon is more evident in mitochondria that have incorporated ubiquinone-3 and might be ascribed to an ordering structural effect on the lipid bilayer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cabrini L., Landi L., Pasquali P., Lenaz G. Effect of endogenous ubiquinone on the interaction of exogenous Ubiquinone-1 with the respiratory chain of bovine heart mitochondria. Arch Biochem Biophys. 1981 Apr 15;208(1):11–19. doi: 10.1016/0003-9861(81)90117-x. [DOI] [PubMed] [Google Scholar]
  2. Degli Esposti M., Bertoli E., Parenti-Castelli G., Fato R., Mascarello S., Lenaz G. Incorporation of ubiquinone homologs into lipid vesicles and mitochondrial membranes. Arch Biochem Biophys. 1981 Aug;210(1):21–32. doi: 10.1016/0003-9861(81)90159-4. [DOI] [PubMed] [Google Scholar]
  3. HUNTER F. E., Jr, SCOTT A., HOFFSTEN P. E., GUERRA F., WEINSTEIN J., SCHNEIDER A., SCHUTZ B., FINK J., FORD L., SMITH E. STUDIES ON THE MECHANISM OF ASCORBATE-INDUCED SWELLING AND LYSIS OF ISOLATED LIVER MITOCHANDRIA. J Biol Chem. 1964 Feb;239:604–613. [PubMed] [Google Scholar]
  4. Katsikas H., Quinn P. J. The polyisoprenoid chain length influences the interaction of ubiquinones with phospholipid bilayers. Biochim Biophys Acta. 1982 Jul 28;689(2):363–369. doi: 10.1016/0005-2736(82)90270-x. [DOI] [PubMed] [Google Scholar]
  5. Kröger A., Klingenberg M. The kinetics of the redox reactions of ubiquinone related to the electron-transport activity in the respiratory chain. Eur J Biochem. 1973 Apr;34(2):358–368. doi: 10.1111/j.1432-1033.1973.tb02767.x. [DOI] [PubMed] [Google Scholar]
  6. Landi L., Pasquali P., Cabrini L., Sechi A. M., Lenaz G. On the mechanism of inhibition of NADH oxidase by ubiquinone-3. J Bioenerg Biomembr. 1984 Apr;16(2):153–166. doi: 10.1007/BF00743046. [DOI] [PubMed] [Google Scholar]
  7. Lenaz G., Landi L., Cabrini L., Pasquali P., Sechi A. M., Ozawa T. On the sidedness of the ubiquinone redox cycle. Kinetic studies in mitochondrial membranes. Biochem Biophys Res Commun. 1978 Dec 14;85(3):1047–1053. doi: 10.1016/0006-291x(78)90648-4. [DOI] [PubMed] [Google Scholar]
  8. Lenaz G., Pasquali P., Bertoli E., Parenti-Castelli G. The inhibition of NADH oxidase by the lower homologs of coenzyme Q. Arch Biochem Biophys. 1975 Jul;169(1):217–226. doi: 10.1016/0003-9861(75)90335-5. [DOI] [PubMed] [Google Scholar]
  9. MCKNIGHT R. C., HUNTER F. E., Jr, OEHLERT W. H. MITOCHONDRIAL MEMBRANE GHOSTS PRODUCED BY LIPID PEROXIDATION INDUCED BY FERROUS ION. I. PRODUCTION AND GENERAL MORPHOLOGY. J Biol Chem. 1965 Aug;240:3439–3445. [PubMed] [Google Scholar]
  10. McKnight R. C., Hunter F. E., Jr Mitochondrial membrane ghosts produced by lipid peroxidation induced by ferrous ion. II. Composition and enzymatic activity. J Biol Chem. 1966 Jun 25;241(12):2757–2765. [PubMed] [Google Scholar]
  11. Mellors A., Tappel A. L. The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem. 1966 Oct 10;241(19):4353–4356. [PubMed] [Google Scholar]
  12. Norling B., Glazek E., Nelson B. D., Ernster L. Studies with ubiquinone-depleted submitochondrial particles. Quantitative incorporation of small amounts of ubiquinone and its effects on the NADH and succinate oxidase activities. Eur J Biochem. 1974 Sep 16;47(3):475–482. doi: 10.1111/j.1432-1033.1974.tb03715.x. [DOI] [PubMed] [Google Scholar]
  13. Pasquali P., Landi L., Cabrini L., Lenaz G. Effect of ubiquinone extraction on ubiquinol-1 oxidase activity in beef heart mitochondria. J Bioenerg Biomembr. 1981 Aug;13(3-4):141–148. doi: 10.1007/BF00763836. [DOI] [PubMed] [Google Scholar]
  14. Pfeifer P. M., McCay P. B. Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. VI. Structural changes in mitochondria associated with inactivation of electron transport activity. J Biol Chem. 1972 Nov 10;247(21):6763–6769. [PubMed] [Google Scholar]
  15. Szarkowska L. The restoration of DPNH oxidase activity by coenzyme Q (ubiquinone). Arch Biochem Biophys. 1966 Mar;113(3):519–525. doi: 10.1016/0003-9861(66)90228-1. [DOI] [PubMed] [Google Scholar]
  16. Takayanagi R., Takeshige K., Minakami S. NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol. Biochem J. 1980 Dec 15;192(3):853–860. doi: 10.1042/bj1920853. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Takeshige K., Takayanagi R., Minakami S. Lipid peroxidation and the reduction of ADP-Fe3+ chelate by NADH-ubiquinone reductase preparation from bovine heart mitochondria. Biochem J. 1980 Dec 15;192(3):861–866. doi: 10.1042/bj1920861. [DOI] [PMC free article] [PubMed] [Google Scholar]

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