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. 1984 Nov 1;223(3):831–835. doi: 10.1042/bj2230831

Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate.

K Snell, D A Duff
PMCID: PMC1144369  PMID: 6508745

Abstract

Dichloroacetate (which activates pyruvate dehydrogenase) decreases the release of alanine, pyruvate and lactate in hemidiaphragm incubations with valine. Dichloroacetate interferes with alanine formation by diverting pyruvate into oxidative pathways, which not only limits pyruvate availability for direct transamination to form alanine but also indirectly affects branched-chain amino acid transamination by limiting 2-oxoglutarate regeneration from glutamate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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