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. 1984 Dec 1;224(2):461–466. doi: 10.1042/bj2240461

Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.

J Saklatvala, L M Pilsworth, S J Sarsfield, J Gavrilovic, J K Heath
PMCID: PMC1144453  PMID: 6097218

Abstract

Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.

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Selected References

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