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. 1985 Jan 1;225(1):255–258. doi: 10.1042/bj2250255

Glucocorticoids induce the expression of the uteroglobin gene in rabbit foetal lung explants cultured in vitro.

M S López de Haro, A Nieto
PMCID: PMC1144577  PMID: 3977827

Abstract

In 27-day-old rabbit foetal lung explants cultured in vitro, the synthesis of the protein uteroglobin decreased progressively during several days of culture. Addition of glucocorticoids to the medium progressively induced the synthesis of uteroglobin in a dose-dependent manner without affecting the synthesis of total proteins. The glucocorticoid-mediated induction of uteroglobin appears mainly due to increased amounts of uteroglobin mRNA and seems to be independent of simultaneous cell proliferation, suggesting a glucocorticoid-triggered differentiation of pre-existing cells. The results suggest a major role of glucocorticoids in the developmental regulation of the uteroglobin gene in the lung.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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