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. 1985 Apr 1;227(1):67–71. doi: 10.1042/bj2270067

Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats.

R Deacon, J Perry, M Lumb, I Chanarin
PMCID: PMC1144809  PMID: 3994693

Abstract

N2O oxidizes and inactivates cob[I]alamin, and animals exposed in this way serve as models for cobalamin 'deficiency'. Such animals show a fall in activity of glycinamide ribotide transformylase and a rise in that of 5-amino-4-imidazolecarboxamide ribotide transformylase. The fall in glycinamide ribotide transformylase activity was prevented by parenteral 5'-methylthioadenosine derived from methionine. Methylthioadenosine in turn is converted into formate. Activity of glycinamide ribotide transformylase recovers after 7 days despite continued N2O inhalation, and this is probably related to restoration of methionine synthesis by induction of betaine:homocysteine transmethylase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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