Table 2:
CPX-351 | All | 50 units/m2 | 75 units/m2 | 100 units/m2 | P |
---|---|---|---|---|---|
| |||||
CR | 16 (29) | 3 (19) | 6 (25) | 7 (44) | |
CRi | 3 (5) | 0 | 3 (13) | 0 | |
CR+CRi | 19 (34) | 3 (19) | 9 (38) | 7 (44) | 0.35* |
Treatment failure | 37 (66) | 13 (81) | 15 (62) | 9 (56) | |
No response | 36 (64) | 13 (81) | 14 (58) | 9 (56) | |
Death in aplasia | 0 | 0 | 0 | 0 | |
Death from indeterminate cause | 1 (2) | 0 | 1 (4) | 0 | |
MRD negative | 4 (21)^ | 0 | 1 (4) | 3 (19) | 0.16 |
Values are n (%). Abbreviations: CR, complete response; CRi, CR with incomplete hematologic recovery; MRD, minimal residual disease: assessed following induction.
Comparison of CR+CRi among 3 cohorts.
Four (21%) of the 19 patients that achieved CR/CRi had undetectable MRD following induction.