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. 1985 Jul 15;229(2):453–458. doi: 10.1042/bj2290453

Ionophore activity of sarcotoxin I, a bactericidal protein of Sarcophaga peregrina.

M Okada, S Natori
PMCID: PMC1145077  PMID: 3899107

Abstract

When Escherichia coli was treated with sarcotoxin I, a potent bactericidal protein of Sarcophaga peregrina (fleshfly), K+ inside of the cells leaked out rapidly and the ATP pool of the cells rapidly decreased. These results suggested that the bactericidal effect of sarcotoxin I was due to its ionophore activity, and that it blocked the generation of ATP by inhibiting formation of the proton gradient essential for oxidative phosphorylation. This was confirmed by use of an uncA mutant, which was much less susceptible than the wild-type strain to sarcotoxin I under fixed ionic conditions.

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Selected References

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