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. 1985 Aug 1;229(3):807–810. doi: 10.1042/bj2290807

Inhibition of rat heart ornithine decarboxylase by basic polypeptides.

F Flamigni, C Guarnieri, S Marmiroli, C M Caldarera
PMCID: PMC1145128  PMID: 4052027

Abstract

Purified and partially purified ornithine decarboxylase (ODC) from rat heart was inhibited by basic polypeptides in vitro. Poly-L-arginine, the most effective, was inhibitory at a concentration as low as 0.1 microgram/ml; protamine and histone clearly inhibited ODC at concentrations higher than 2 micrograms/ml, but poly-L-lysine was less effective. The ability to inhibit ODC appeared to correlate with the arginine-residue content of basic polypeptides. The inhibition effect could be decreased by increasing substrate concentration and ionic strength.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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