Abstract
Synergy between sulphadiazine and trimethoprim against Escherichia coli has been demonstrated in culture media not containing lysed horse blood despite the presence of pus or a pus extract which inhibited the action of each drug separately. Synergy may therefore be important where pus is present in vivo.
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- Bushby S. R. Combined antibacterial action in vitro of trimethoprim and sulphonamides. The in vitro nature of synergy. Postgrad Med J. 1969 Nov;45(Suppl):10–18. [PubMed] [Google Scholar]
- Darrell J. H., Garrod L. P., Waterworth P. M. Trimethoprim: laboratory and clinical studies. J Clin Pathol. 1968 Mar;21(2):202–209. doi: 10.1136/jcp.21.2.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenwood D., O'Grady F. Activity and interaction of trimethoprim and sulphamethoxazole against Escherichia coli. J Clin Pathol. 1976 Feb;29(2):162–166. doi: 10.1136/jcp.29.2.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewis E. L., Anderson J. D., Lacey R. W. A reappraisal of the antibacterial action of cotrimoxazole in vitro. J Clin Pathol. 1974 Feb;27(2):87–91. doi: 10.1136/jcp.27.2.87. [DOI] [PMC free article] [PubMed] [Google Scholar]