Abstract
Thirty-five patients with haemophilia A were studied clinically and serologically between 1971-2 and 1975-6 for evidence of hepatitis B infection. One patient suffered from clinical hepatitis B, and a further eight patients showed antibody responses to hepatitis B surface antigen (HBsAg) consistent with exposure to HBsAg during this period. No evidence for HBsAg exposure was found in 14 patients, while the remaining 12 patients had high titres of antibody to HBsAg at both times and no inferences could be drawn about HBsAg exposure. All patients had received exclusively replacement factor VIII material prepared locally from HBsAg-screened voluntary Scottish blood donations. From the details of the therapy given we calculated that the rate of HBsAg seroconversion in these patients represented about 0.3 HBsAg-containing donations/1000 donations.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Biggs R. Jaundice and antibodies directed against factors 8 and 9 in patients treated for haemophilia or Christmas disease in the United Kingdom. Br J Haematol. 1974 Mar;26(3):313–329. doi: 10.1111/j.1365-2141.1974.tb00476.x. [DOI] [PubMed] [Google Scholar]
- Burrell C. J., Parker A. C., Ramsay D. M., Proudfoot E. Antibody to hepatitis B antigen in haemophiliacs and their household contacts. J Clin Pathol. 1974 Apr;27(4):323–325. doi: 10.1136/jcp.27.4.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burrell C. J., Tonkin R. W., Proudfoot E., Leadbetter G., Cowan P., Lockerbie L., Gore S., Lutz W., Marmion B. P. Prevalence of antibody to hepatitits B surface antigen among staff in an Edinburgh hospital. J Hyg (Lond) 1977 Feb;78(1):57–68. doi: 10.1017/s0022172400055935. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldfield M., Black H. C., Bill J., Srihongse S., Pizzuti W. The consequences of administering blood pretested for HBs Ag by third generation techniques: a progress report. Am J Med Sci. 1975 Sep-Oct;270(2):335–342. doi: 10.1097/00000441-197509000-00015. [DOI] [PubMed] [Google Scholar]
- Holsteen V., Skinhoj P., Cohn J. Hepatitis, type B in haemophiliacs. Relation to the source of clotting factor concentrates. Scand J Haematol. 1977 Mar;18(3):214–218. [PubMed] [Google Scholar]
- Hoofnagle J. H., Gerety R. J., Barker L. F. Hepatitis B core antigen and antibody. Dev Biol Stand. 1975;30:175–185. [PubMed] [Google Scholar]
- Hopkins R., Das P. C. A tanned cell haemagglutination test for the detection of hepatitis-associated-antigen (Au-Ag) and antibody (anti-Au). Br J Haematol. 1973 Nov;25(5):619–629. doi: 10.1111/j.1365-2141.1973.tb01775.x. [DOI] [PubMed] [Google Scholar]
- Islam M. N., Banatvala J. E. The prevalence of hepatitis-B antigen (HB S Ag) and its antibody (Anti-HB S) among London hemophiliacs and blood donors from London and two tropical areas. Transfusion. 1976 May-Jun;16(3):237–241. doi: 10.1046/j.1537-2995.1976.16376225495.x. [DOI] [PubMed] [Google Scholar]
- James H. L., Wickerhauser M. Development of large-scale fractionation methods. 3. Preparation of a factor VIII concentrate of intermediate-purity. Vox Sang. 1972;23(5):402–412. doi: 10.1111/j.1423-0410.1972.tb03827.x. [DOI] [PubMed] [Google Scholar]
- Newman J., Johnson A. J., Karpatkin M. H., Puszkin S. Methods for the production of clinically effective intermediate- and high-purity factor-VIII concentrates. Br J Haematol. 1971 Jul;21(1):1–20. doi: 10.1111/j.1365-2141.1971.tb03413.x. [DOI] [PubMed] [Google Scholar]
- POOL J. G., GERSHGOLD E. J., PAPPENHAGEN A. R. HIGH-POTENCY ANTIHAEMOPHILIC FACTOR CONCENTRATE PREPARED FROM CRYOGLOBULIN PRECIPITATE. Nature. 1964 Jul 18;203:312–312. doi: 10.1038/203312a0. [DOI] [PubMed] [Google Scholar]
- Peterson M. R., Barker L. F., Schade D. S. Detection of antibody to hepatitis-associated antigen in hemophilia patients and in voluntary blood donors. Vox Sang. 1973 Jan;24(1):66–75. doi: 10.1111/j.1423-0410.1973.tb03858.x. [DOI] [PubMed] [Google Scholar]