Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1978 May;31(5):461–468. doi: 10.1136/jcp.31.5.461

Cell receptor studies on six anaplastic tumours of the thyroid.

R A Macaulay, A E Dewar, A O Langlands, A E Stuart
PMCID: PMC1145304  PMID: 649772

Abstract

Cell suspensions from six anaplastic thyroid tumours were studied for expression of lymphocyte and macrophage surface markers, and results were correlated with electron microscopy, clinical extent of disease, and response to radiotherapy. The clinical presentation of the disease was similar in all six patients. In five cases, many of the cells showed surface immunoglobulin. Electron microscopy was available on three of these and showed appearances in keeping with malignant lymphoma. The single case whose cells did not show surface immunoglobulin had an entirely different ultrastructure and was probably a carcinoma. This case was the only one that did not achieve complete remission with radiotherapy and the patient died from extensive local recurrence. It is concluded that receptor techniques are of value in distinguishing between malignant lymphoma and other anaplastic tumours of the thyroid, particularly when the results are correlated with histology.

Full text

PDF
461

Images in this article

464Fig. 1
on p.464
464Fig. 2
on p.464
465Fig. 3
on p.465
466Fig. 1
on p.466

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BREWER D. B., ORR J. W. Struma reticulosa: a reconsideration of the undifferentiated tumours of the thyroid. J Pathol Bacteriol. 1953 Jan;65(1):193–208. doi: 10.1002/path.1700650121. [DOI] [PubMed] [Google Scholar]
  2. Bloomfield C. D., Kersey J. H., Brunning R. D., Gajl-Peczalska K. J. Prognostic significance of lymphocyte surface markers in adult non-Hodgkin's malignant lymphoma. Lancet. 1976 Dec 18;2(7999):1330–1333. doi: 10.1016/s0140-6736(76)91976-0. [DOI] [PubMed] [Google Scholar]
  3. Brouet J. C., Labaume S., Seligmann M. Evaluation of T and B lymphocyte membrane markers in human non-Hodgkin malignant lymphomata. Br J Cancer Suppl. 1975 Mar;2:121–127. [PMC free article] [PubMed] [Google Scholar]
  4. Burke J. S., Butler J. J., Fuller L. M. Malignant lymphomas of the thyroid: a clinical pathologic study of 35 patients including ultrastructural observations. Cancer. 1977 Apr;39(4):1587–1602. doi: 10.1002/1097-0142(197704)39:4<1587::aid-cncr2820390434>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  5. Cameron R. G., Seemayer T. A., Wang N. S., Ahmed M. N., Tabah E. J. Small cell malignant tumors of the thyroid. A light and electron microscopic study. Hum Pathol. 1975 Nov;6(6):731–740. doi: 10.1016/s0046-8177(75)80081-5. [DOI] [PubMed] [Google Scholar]
  6. Fisher E. R., Gregorio R., Shoemaker R., Horvat B., Hubay C. The derivation of so-called "giant-cell" and "spindle-cell" undifferentiated thyroidal neoplasms. Am J Clin Pathol. 1974 May;61(5):680–689. doi: 10.1093/ajcp/61.5.680. [DOI] [PubMed] [Google Scholar]
  7. Gaal J. M., Horvath E., Kovacs K. Ultrastructure of two cases of anaplastic giant cell tumor of the human thyroid gland. Cancer. 1975 May;35(5):1273–1279. doi: 10.1002/1097-0142(197505)35:5<1273::aid-cncr2820350502>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  8. Glick A. D., Leech J. H., Waldron J. A., Flexner J. M., Horn R. G., Collins R. D. Malignant lymphomas of follicular center cell origin in man. II. Ultrastructural and cytochemical studies. J Natl Cancer Inst. 1975 Jan;54(1):23–36. doi: 10.1093/jnci/54.1.23. [DOI] [PubMed] [Google Scholar]
  9. Gonzalez-Crussi F. Ultrastructure of congenital fibrosarcoma. Cancer. 1970 Dec;26(6):1289–1299. doi: 10.1002/1097-0142(197012)26:6<1289::aid-cncr2820260616>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  10. Graham H., Daniel C. Ultrastructure of an anaplastic carcinoma of the thyroid. Am J Clin Pathol. 1974 May;61(5):690–696. doi: 10.1093/ajcp/61.5.690. [DOI] [PubMed] [Google Scholar]
  11. Habeshaw J. A., Macaulay R. A., Stuart A. E. Correlation of surface receptors with histological appearance in 29 cases of non-Hodgkin lymphoma. Br J Cancer. 1977 Jun;35(6):858–867. doi: 10.1038/bjc.1977.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Henry K. Electron microscopy in the non-Hodgkin's lymphomata. Br J Cancer Suppl. 1975 Mar;2:73–93. [PMC free article] [PubMed] [Google Scholar]
  13. Henry K., Farrer-Brown G. Primary lymphomas of the gastrointestinal tract. I. Plasma cell tumours. Histopathology. 1977 Jan;1(1):53–76. doi: 10.1111/j.1365-2559.1977.tb01644.x. [DOI] [PubMed] [Google Scholar]
  14. Jao W., Gould V. E. Ultrastructure of anaplastic (spindle and giant cell) carcinoma of the thyroid. Cancer. 1975 May;35(5):1280–1292. doi: 10.1002/1097-0142(197505)35:5<1280::aid-cncr2820350503>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  15. Levine G. D., Dorfman R. F. Nodular lymphoma: an ultrastructural study of its relationship to germinal centers and a correlation of light and electron microscopic findings. Cancer. 1975 Jan;35(1):148–164. doi: 10.1002/1097-0142(197501)35:1<148::aid-cncr2820350121>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  16. MEISSNER W. A., PHILLIPS M. J. Diffuse small-cell carcinoma of the thyroid. Arch Pathol. 1962 Oct;74:291–297. [PubMed] [Google Scholar]
  17. METCALFE W. J., SCLARE G. Primary lymphosarcoma of the thyroid. Br J Surg. 1961 Mar;48:541–549. doi: 10.1002/bjs.18004821118. [DOI] [PubMed] [Google Scholar]
  18. Nossal G. J., Abbot A., Mitchell J., Lummus Z. Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J Exp Med. 1968 Feb 1;127(2):277–290. doi: 10.1084/jem.127.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Ross R., Odland G. Human wound repair. II. Inflammatory cells, epithelial-mesenchymal interrelations, and fibrogenesis. J Cell Biol. 1968 Oct;39(1):152–168. doi: 10.1083/jcb.39.1.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Salmon S. E., Seligmann M. B-cell neoplasia in man. Lancet. 1974 Nov 23;2(7891):1230–1233. doi: 10.1016/s0140-6736(74)90748-x. [DOI] [PubMed] [Google Scholar]
  21. Stuart A. E., Davidson A. E. The human reticular cell: morphology and cytochemistry. J Pathol. 1971 Jan;103(1):41–47. doi: 10.1002/path.1711030106. [DOI] [PubMed] [Google Scholar]
  22. Taylor C. R., Burns J. The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. J Clin Pathol. 1974 Jan;27(1):14–20. doi: 10.1136/jcp.27.1.14. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES