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. 1978 Aug;31(8):749–752. doi: 10.1136/jcp.31.8.749

Histamine release reaction of basophils in chronic granulocytic leukaemia. Induction by heterologous anti-immunoglobulin E, concanavaline A, and phytohaemagglutinin; effect of heavy water.

G Sebahoun, D Vervloet, J Charpin, Y Carcassonne
PMCID: PMC1145400  PMID: 80409

Abstract

Basophils possess membrane bound IgE molecules, and immunological activation leads to a secretory process with cell degranulation and histamine release. Heterologous anti IgE, concanavaline A, and phytohaemagglutinin are potent non-cytotoxic releasing agents. They operate by a mechanism similar to that of immunological activation. Heavy water is not a histamine releasing inducer but it increases histamine release of the cells. We studied the histamine release reaction of leukaemic basophils in 10 patients and found a physiological response such as that previously reported with normal human basophils.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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