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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1978 Aug;31(8):765–771. doi: 10.1136/jcp.31.8.765

Splenic lipidosis after administration of intravenous fat emulsions.

G B Forbes
PMCID: PMC1145404  PMID: 690241

Abstract

Spleens showing fatty infiltration and necrosis of the pulp were found at necropsy on several patients who had received intravenous fat emulsions during their terminal illnesses. The postmortem findings are described and the clinicopathological correlation is discussed with special reference to the phenomenon of creaming of the emulsion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOZIAN R. C., DAVIDSON N. W., STUTMAN L. J., WILKINSON C. F., Jr Observations on the use of intravenous fat emulsions in man. Metabolism. 1957 Nov;6(6 Pt 2):703–716. [PubMed] [Google Scholar]
  2. Freund U., Krausz Y., Levij I. S., Eliakim M. Latrogenic lipidosis following prolonged intravenous hyperalimentation. Am J Clin Nutr. 1975 Oct;28(10):1156–1160. doi: 10.1093/ajcn/28.10.1156. [DOI] [PubMed] [Google Scholar]
  3. HADFIELD J. I. PREOPERATIVE AND POSTOPERATIVE INTRAVENOUS FAT THERAPY. Br J Surg. 1965 Apr;52:291–298. doi: 10.1002/bjs.1800520412. [DOI] [PubMed] [Google Scholar]
  4. LEVEEN H. H., GIORDANO P., JOHNSON A. FLOCCULATION OF INTRAVENOUS FAT EMULSIONS. Am J Clin Nutr. 1965 Jan;16:129–134. doi: 10.1093/ajcn/16.1.129. [DOI] [PubMed] [Google Scholar]
  5. LEVEEN H. H., GIORDANO P., SPLETZER J. Mechanism of removal of intravenously injected fat. Its relationship to toxioity. Arch Surg. 1961 Aug;83:311–321. doi: 10.1001/archsurg.1961.01300140153029. [DOI] [PubMed] [Google Scholar]
  6. Lawson L. J. Parenteral nutrition in surgery. Br J Surg. 1965 Oct;52(10):795–800. doi: 10.1002/bjs.1800521023. [DOI] [PubMed] [Google Scholar]
  7. Lee H. A., Sharpstone P., Ames A. C. Parenteral nutrition in renal failure. Postgrad Med J. 1967 Feb;43(496):81–91. doi: 10.1136/pgmj.43.496.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nicholls P. D. The erroneous haemoglobin-hyperlipidaemia relationship. J Clin Pathol. 1977 Jul;30(7):638–640. doi: 10.1136/jcp.30.7.638. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Passwell J. H., David R., Katznelson D., Cohen B. E. Pigment deposition in the reticuloendothelial system after fat emulsion infusion. Arch Dis Child. 1976 May;51(5):366–368. doi: 10.1136/adc.51.5.366. [DOI] [PMC free article] [PubMed] [Google Scholar]

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