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. 1978 Sep;31(9):840–844. doi: 10.1136/jcp.31.9.840

Prevalence of pathogenic yeasts and humoral antibodies to candida in diabetic patients.

F C Odds, E G Evans, M A Taylor, J K Wales
PMCID: PMC1145426  PMID: 711913

Abstract

The prevalence of oral yeasts and humoral precipitating antibodies to candida was estimated in 204 unselected diabetic patients (172 outpatients and 32 inpatients). Yeasts, mainly Candida albicans, were isolated from the mouths of 41% of the outpatients and precipitins were found in 17.5% although none of the patients had clinically overt candidiasis. The extent of oral yeast colonisation and incidence of antibodies was not related to their antidiabetic treatment or to the duration of their diabetes. It was, however, related to the blood glucose and urine sugar levels at the time they were sampled, the highest incidence being among the diabetic inpatients with high blood glucose levels at the time of sampling and the lowest among outpatients with normal blood glucose levels at the time of sampling. There was no such correlation when diabetic control over the previous 12-month period was considered.

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Selected References

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  1. ANDRIOLE V. T., HASENCLEVER H. F. Factors influencing experimental candidiasis in mice. I. Alloxan diabetes. Yale J Biol Med. 1962 Aug;35:96–112. [PMC free article] [PubMed] [Google Scholar]
  2. Barlow A. J., Chattaway F. W. Observations on the carriage of Candida albicans in man. Br J Dermatol. 1969 Feb;81(2):103–106. doi: 10.1111/j.1365-2133.1969.tb15988.x. [DOI] [PubMed] [Google Scholar]
  3. Berdon J. K., Seita C. L. The incidence of Candida albicans in hospital patients. J Oral Med. 1971 Dec;26(3):123–126. [PubMed] [Google Scholar]
  4. Evans E. G., Forster R. A. Antibodies to Candida after operations on the heart. J Med Microbiol. 1976 Aug;9(3):303–308. doi: 10.1099/00222615-9-3-303. [DOI] [PubMed] [Google Scholar]
  5. Evans E. G. The incidence of pathogenic yeasts among open-heart surgery patients-the value of prophylaxis. J Thorac Cardiovasc Surg. 1975 Sep;70(3):466–470. [PubMed] [Google Scholar]
  6. HESSELTINE H. C. Vulvitis: due to mycosis, atrophy, and avitaminosis. Am Pract Dig Treat. 1955 Jun;6(6):864–867. [PubMed] [Google Scholar]
  7. Hurley R. Experimental infection with Candida albicans in modified hosts. J Pathol Bacteriol. 1966 Jul;92(1):57–67. doi: 10.1002/path.1700920108. [DOI] [PubMed] [Google Scholar]
  8. Knight L., Fletcher J. Growth of Candida albicans in saliva: stimulation by glucose associated with antibiotics, corticosteroids, and diabetes mellitus. J Infect Dis. 1971 Apr;123(4):371–377. doi: 10.1093/infdis/123.4.371. [DOI] [PubMed] [Google Scholar]
  9. Louria D. B., Busé M., Brayton R. G., Finkel G. The pathogenesis of Candida tropicalis infections in mice. Sabouraudia. 1966 Jun;5(1):14–25. [PubMed] [Google Scholar]
  10. MACKENZIE D. W. Yeasts from human sources. Sabouraudia. 1961 Jan;1:8–15. doi: 10.1080/00362176285190051. [DOI] [PubMed] [Google Scholar]
  11. McKendrick A. J., Wilson M. I., Main D. M. Oral Candida and long-term tetracycline therapy. Arch Oral Biol. 1967 Feb;12(2):281–290. doi: 10.1016/0003-9969(67)90047-7. [DOI] [PubMed] [Google Scholar]
  12. Murray I. G., Buckley H. R., Turner G. C. Serological evidence of Candida infection after open-heart surgery. J Med Microbiol. 1969 Nov 4;2(4):463–469. doi: 10.1099/00222615-2-4-463. [DOI] [PubMed] [Google Scholar]
  13. Odds F. C., EVANS E. G., Holland K. T. Detection of Candida precipitins. a comparison of double diffusion and counter immunoelectrophoresis. J Immunol Methods. 1975 Jun;7(2-3):211–218. doi: 10.1016/0022-1759(75)90018-6. [DOI] [PubMed] [Google Scholar]
  14. Peters R. B., Bahn A. N., Barens G. Candida albicans in the oral cavities of diabetics. J Dent Res. 1966 May-Jun;45(3):771–777. doi: 10.1177/00220345660450034601. [DOI] [PubMed] [Google Scholar]
  15. SOMERVILLE D. A. CANDIDA ALBICANS IN A MATERNITY HOSPITAL. N Z Med J. 1964 Sep;63:592–596. [PubMed] [Google Scholar]
  16. SONCK C. E., SOMERSALO O. THE YEAST FLORA OF THE ANOGENITAL REGION IN DIABETIC GIRLS. Arch Dermatol. 1963 Dec;88:846–852. doi: 10.1001/archderm.1963.01590240170029. [DOI] [PubMed] [Google Scholar]
  17. Schmitt J. A. Epidemiological investigations or oral Candida albicans. Mycopathol Mycol Appl. 1971 Jan 25;43(1):65–87. doi: 10.1007/BF02051504. [DOI] [PubMed] [Google Scholar]
  18. Stanley V. C., Hurley R., Carroll C. J. Distribution and significance of candida precipitins in sera from pregnant women. J Med Microbiol. 1972 Aug;5(3):313–320. doi: 10.1099/00222615-5-3-313. [DOI] [PubMed] [Google Scholar]
  19. Stone H. H., Geheber C. E., Kolb L. D., Kitchens W. R. Alimentary tract colonization by Candida albicans. J Surg Res. 1973 Apr;14(4):273–276. doi: 10.1016/0022-4804(73)90028-0. [DOI] [PubMed] [Google Scholar]
  20. Stone H. H., Kolb L. D., Currie C. A., Geheber C. E., Cuzzell J. Z. Candida sepsis: pathogenesis and principles of treatments. Ann Surg. 1974 May;179(5):697–711. doi: 10.1097/00000658-197405000-00024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. TASCHDJIAN C. L., BURCHALL J. J., KOZINN P. J. Rapid identification of Candida albicans by filamentation on serum and serum substitutes. AMA J Dis Child. 1960 Feb;99:212–215. doi: 10.1001/archpedi.1960.02070030214011. [DOI] [PubMed] [Google Scholar]
  22. Van Cutsem J., Thienpont D. Experimental cutaneous Candida albicans infection in guinea-pigs. Sabouraudia. 1971 Mar;9(1):17–20. [PubMed] [Google Scholar]
  23. Wain W. H., Price M. F., Cawson R. A. Factors affecting plaque formation by Candida albicans infecting the chick chorio-allantoic membrane. Sabouraudia. 1976 Jul;14(2):149–151. [PubMed] [Google Scholar]

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