Abstract
Urine-grown cultures of 23 clinical isolates of Gram-negative bacteria having a range of minimum inhibitory concentration values for chorhexidine were challenged with various concentrations of this antiseptic. The results suggest that cells of Providencia stuartii, in particular, exhibit a considerable degree of resistance to chlorhexidine under these conditions, concentrations of up to 10 000--20 000 microgram/ml of urine being necessary to produce complete loss of viability of such cultures. Of the other two antiseptics tested, phenoxyethanol proved to be the more effective, the recommended use concentration of 2% v/v producing reductions in viable counts of greater than six logarithms in all the strains examined. It is suggested that phenoxyethanol may be a suitable alternative to the cationic agents for use in antiseptic policies for bladder management of urinary tract infections with Providencia stuartii.
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Selected References
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- DUTTON A. A., RALSTON M. Urinary tract infection in a male urological ward; with special reference to the mode of infection. Lancet. 1957 Jan 19;272(6960):115–119. [PubMed] [Google Scholar]
- Desautels R. E. The causes of catheter-induced urinary infections and their prevention. J Urol. 1969 May;101(5):757–760. doi: 10.1016/s0022-5347(17)62419-4. [DOI] [PubMed] [Google Scholar]
- Dobrey R. A hospital study of the Providence group, with particular reference to subgrouping and the possible presence of R factors. Can J Med Technol. 1971 Oct;33(5):177–187. [PubMed] [Google Scholar]
- Gillespie W. A., Lennon G. G., Linton K. B., Phippen G. A. Prevention of urinary infection by means of closed drainage into a sterile plastic bag. Br Med J. 1967 Jul 8;3(5557):90–92. doi: 10.1136/bmj.3.5557.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keane C. T., English L. F., Wise R. Letter: Providencia stuartii infections. Lancet. 1975 Nov 22;2(7943):1045–1045. doi: 10.1016/s0140-6736(75)90341-4. [DOI] [PubMed] [Google Scholar]
- Li K., Miller C. Pathogenic bacteria and their sensitivity patterns in a hospital population of geriatric patients with chronic disease. J Am Geriatr Soc. 1970 Apr;18(4):286–294. doi: 10.1111/j.1532-5415.1970.tb03181.x. [DOI] [PubMed] [Google Scholar]
- Milner P. F. The differentiation of Enterobacteriaceae infecting the urinary tract: A study in male paraplegics. J Clin Pathol. 1963 Jan;16(1):39–45. doi: 10.1136/jcp.16.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Solberg C. O., Matsen J. M. Infections with Providence bacilli. A clinical and bacteriologic study. Am J Med. 1971 Feb;50(2):241–246. doi: 10.1016/0002-9343(71)90153-7. [DOI] [PubMed] [Google Scholar]
- Stickler D. J. Chlorhexidine resistance in Proteus mirabilis. J Clin Pathol. 1974 Apr;27(4):284–287. doi: 10.1136/jcp.27.4.284. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stickler D. J., Thomas B. Sensitivity of Providence to antiseptics and disinfectants. J Clin Pathol. 1976 Sep;29(9):815–823. doi: 10.1136/jcp.29.9.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stickler D. J., Wilmont C. B., O'Flynn J. D. The mode of development of urinary infection in intermittently catheterised male paraplegics. Paraplegia. 1971 Feb;8(4):243–252. doi: 10.1038/sc.1970.43. [DOI] [PubMed] [Google Scholar]
- von Graevenitz A., Nourbakhsh M. Antimicrobial resistance of the genera Proteus, Providencia and Serratia with special reference to multiple resistance patterns. Med Microbiol Immunol. 1972;157(2):142–148. doi: 10.1007/BF02124474. [DOI] [PubMed] [Google Scholar]