Abstract
Two cases of congestive cardiac failure had unusually high activities of serum lactate dehydrogenase and lactate dehydrogenase isoenzyme-5. Values for isoenzyme-5 exceeding 87% of the total serum activity, and increases of 228- to 380-fold of the upper reference limit, are very uncommon.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dunn G. D., Hayes P., Breen K. J., Schenker S. The liver in congestive heart failure: a review. Am J Med Sci. 1973 Mar;265(3):174–189. doi: 10.1097/00000441-197303000-00001. [DOI] [PubMed] [Google Scholar]
- Henderson A. R., Grace D. M. Liver-originating isoenzymes of alkaline phosphatase in the serum: a paraneoplastic manifestation of a malignant schwannoma of the sciatic nerve. J Clin Pathol. 1976 Mar;29(3):237–240. doi: 10.1136/jcp.29.3.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henderson A. R., Kostuk W. J., Griffiths J. C. Increased lactate dehydrogenase isoenzyme-5 (LD5) activity evidently caused by persistent diaphragmatic pressure on a congested liver. Clin Chem. 1973 Nov;19(11):1300–1301. [PubMed] [Google Scholar]
- McKenzie D., Clark P. I., Henderson A. R. How accurate are lactate dehydrogenase isoenzyme estimations by the thin-layer agarose fluorescent technique? Clin Chem. 1976 Dec;22(12):1995–1998. [PubMed] [Google Scholar]
- McKenzie D., Henderson A. R. The effect of dilution and substrate repletion on the LDH isoenzyme distribution of sera with high LDH activities. Clin Chim Acta. 1974 Jan 19;50(1):147–150. doi: 10.1016/0009-8981(74)90087-4. [DOI] [PubMed] [Google Scholar]
- Nathan L. E., Jr, Feldbruegge D., Westgard J. O. Application of an automated determination of isoenzyme-5 of lactage dehydrogenase to the diagnosis of hepatic disease. Clin Chem. 1973 Sep;19(9):1036–1039. [PubMed] [Google Scholar]
- Roman W. Quantitative estimation of lactate dehydrogenase isoenzymes in serum. I. Review of methods and distribution in human tissues. Enzymologia. 1969;36(4):189–219. [PubMed] [Google Scholar]
- Shikata T., Uzawa T., Yoshiwara N., Akatsuka T., Yamazaki S. Staining methods of Australia antigen in paraffin section--detection of cytoplasmic inclusion bodies. Jpn J Exp Med. 1974 Feb;44(1):25–36. [PubMed] [Google Scholar]
- Verel D., Warrack A. J., Potter C. W., Ward C., Rickards D. F. Observations on the A2 England influenza epidemic: a clinicopathological study. Am Heart J. 1976 Sep;92(3):290–296. doi: 10.1016/s0002-8703(76)80109-3. [DOI] [PubMed] [Google Scholar]
- Wallerstedt S., Olsson R., Waldenström J. The diagnostic significance of a high ASAT-ALAT (GOT-GPT) ratio in patients with very high serum aminotransferase levels. Acta Med Scand. 1974 Mar;195(3):227–229. [PubMed] [Google Scholar]
- Zondag H. A., Klein F. Clinical applications of lactate dehydrogenase isozymes: alterations in malignancy. Ann N Y Acad Sci. 1968 Jun 14;151(1):578–586. doi: 10.1111/j.1749-6632.1968.tb11917.x. [DOI] [PubMed] [Google Scholar]
