Abstract
Because of the technical problems and length of time involved in the satisfactory performance of the haemagglutination-inhibition test for detection of rubella-specific antibodies, a commercially available passive haemagglutination (PHA) kit utilising rubella antigen-sensitised human erythrocytes was tested for its suitability for use in diagnostic laboratories. The immune response to acute rubella infections as measured by PHA was considerably delayed compared to the response measured by haemagglutination-inhitition. Titres of rubella-specific antibody only became comparable six months after the infection. The commercially available PHA kits is a useful addition to diagnostic laboratories for the determination of immune status and, in conjunction with the haemagglutination-inhibition test, can be an indicator of recent rubella infection.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dudgeon J. A. Maternal rubella and its effect on the foetus. Arch Dis Child. 1967 Apr;42(222):110–125. doi: 10.1136/adc.42.222.110. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Forbes J. A., Bennett N. M., Kucers A., Lehmann N. I., Ferris A. A. Studies in rubella: observations in elective infection of human volunteers: clinical and laboratory aspects. Med J Aust. 1969 Mar 1;1(9):440–443. doi: 10.5694/j.1326-5377.1969.tb92207.x. [DOI] [PubMed] [Google Scholar]
- Forrest J. M., Menser M. A. Recent implications of intrauterine and postnatal rubella. Aust Paediatr J. 1975 Jun;11(2):65–75. doi: 10.1111/j.1440-1754.1975.tb02283.x. [DOI] [PubMed] [Google Scholar]
- Lehmann N. I., Ferris A. A., Bennett N. M., Newman J. W. Rubella: results of a serological survey of pregnant patients in Melbourne during 1968. Med J Aust. 1969 Jun 21;1(25):1282–1283. doi: 10.5694/j.1326-5377.1969.tb62350.x. [DOI] [PubMed] [Google Scholar]