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. 1979 Feb;32(2):171–178. doi: 10.1136/jcp.32.2.171

Gastin cells and fasting gastrin levels in duodenal ulcer patients: a quantitative study based on multiple biopsy specimens.

J Piris, R Whitehead
PMCID: PMC1145605  PMID: 438346

Abstract

The number of gastrin-producing cells in biopsy specimens from the gastric and duodenal mucosae in 19 duodenal ulcer patients was quantitated using a morphometric method. The level of immunoreactive gastrin in a sample of fasting serum obtained at the time of the biopsy was measured by radioimmunoassay. The results show no significant difference when compared with those from a group of normal control volunteers. Moreover, there was no correlation between the numbers of gastrin-producing cells and the fasting serum gastrin level in either controls or duodenal ulcer patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cowley D. J., Dymock I. W., Boyes B. E., Wilson R. Y., Stagg B. H., Lewin M. R., Polak J. M., Pearse A. G. Zollinger-Ellison syndrome type 1: clinical and pathological correlations in a case. Gut. 1973 Jan;14(1):25–29. doi: 10.1136/gut.14.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Creutzfeldt W., Arnold R., Creutzfeldt C., Track N. S. Mucosal gastrin concentration, molecular forms of gastrin, number and ultrastructure of G-cells in patients with duodenal ulcer. Gut. 1976 Oct;17(10):745–754. doi: 10.1136/gut.17.10.745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dunnill M. S., Whitehead R. A method for the quantitation of small intestinal biopsy specimens. J Clin Pathol. 1972 Mar;25(3):243–246. doi: 10.1136/jcp.25.3.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ganguli P. C., Hunter W. M. Radio-immunoassay of gastrin in human plasma. J Physiol. 1972 Jan;220(2):499–510. [PMC free article] [PubMed] [Google Scholar]
  5. Ganguli P. C., Polak J. M., Pearse A. G., Elder J. B., Hegarty M. Antral-gastrin-cell hyperplasia in peptic-ulcer disease. Lancet. 1974 Apr 6;1(7858):583–586. doi: 10.1016/s0140-6736(74)92647-6. [DOI] [PubMed] [Google Scholar]
  6. Korman M. G., Soveny C., Hansky J. Serum gastrin in duodenal ulcer. I. Basal levels and effect of food and atropine. Gut. 1971 Nov;12(11):899–902. doi: 10.1136/gut.12.11.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McGuigan J. E., Trudeau W. L. Differences in rates of gastrin release in normal persons and patients with duodenal-ulcer disease. N Engl J Med. 1973 Jan 11;288(2):64–66. doi: 10.1056/NEJM197301112880202. [DOI] [PubMed] [Google Scholar]
  8. Nakane P K, Pierce G B., Jr Enzyme-labeled antibodies: preparation and application for the localization of antigens. J Histochem Cytochem. 1966 Dec;14(12):929–931. doi: 10.1177/14.12.929. [DOI] [PubMed] [Google Scholar]
  9. Piris J., Whitehead R. An immunoperoxidase technique for the identification of gastrin-producing cells. J Clin Pathol. 1974 Oct;27(10):798–799. doi: 10.1136/jcp.27.10.798. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Piris J., Whitehead R. Quantitation of G-cells in fibreoptic biopsy specimens and serum gastrin levels in healthy normal subjects. J Clin Pathol. 1975 Aug;28(8):636–638. doi: 10.1136/jcp.28.8.636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Polak J. M., Stagg B., Pearse A. G. Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut. 1972 Jul;13(7):501–512. doi: 10.1136/gut.13.7.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stadil F., Rehfeld J. F. Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay. Scand J Gastroenterol. 1973;8(2):101–112. [PubMed] [Google Scholar]
  13. Stave R., Brandtzaeg P. Immunohistochemical investigation of gastrin-producing cells (G cells).The distribution of g cells in resected human stomachs. Scand J Gastroenterol. 1976;11(7):705–712. [PubMed] [Google Scholar]
  14. Trudeau W. L., McGuigan J. E. Relations between serum gastrin levels and rates of gastric hydrochloric acid secretion. N Engl J Med. 1971 Feb 25;284(8):408–412. doi: 10.1056/NEJM197102252840803. [DOI] [PubMed] [Google Scholar]
  15. Trudeau W. L., McGuigan J. E. Serum gastrin levels in patients with peptic ulcer disease. Gastroenterology. 1970 Jul;59(1):6–12. [PubMed] [Google Scholar]
  16. WEIBEL E. R. Principles and methods for the morphometric study of the lung and other organs. Lab Invest. 1963 Feb;12:131–155. [PubMed] [Google Scholar]

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