Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1979 May;32(5):445–449. doi: 10.1136/jcp.32.5.445

Increased interaction of vascular endothelium and leucocytes after administration of antiplatelet serum: role in the developing vascular defect.

I B Kovacs, J P Caen
PMCID: PMC1145705  PMID: 469002

Abstract

Antiplatelet serum (APS) induced an increase in the stickiness of white cells which manifests itself in the increase in number of granulocytes rolling along or sticking to the venous endothelium. Lidocaine treatment prevented the increased stickiness of white cells and, at the same time, the microvascular haemorrhage developing after APS. It can be assumed that increased stickiness of white cells after APS may contribute to endothelial damage.

Full text

PDF
445

Images in this article

448Fig. 2
on p.448

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACKROYD J. F. Allergic purpura, including purpura due to foods, drugs and infections. Am J Med. 1953 May;14(5):605–632. doi: 10.1016/0002-9343(53)90377-5. [DOI] [PubMed] [Google Scholar]
  2. Atherton A., Born G. V. Quantitative investigations of the adhesiveness of circulating polymorphonuclear leucocytes to blood vessel walls. J Physiol. 1972 Apr;222(2):447–474. doi: 10.1113/jphysiol.1972.sp009808. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BRECHER G., CRONKITE E. P. Morphology and enumeration of human blood platelets. J Appl Physiol. 1950 Dec;3(6):365–377. doi: 10.1152/jappl.1950.3.6.365. [DOI] [PubMed] [Google Scholar]
  4. Fehr J., Jacob H. S. In vitro granulocyte adherence and in vivo margination: two associated complement-dependent functions. Studies based on the acute neutropenia of filtration leukophoresis. J Exp Med. 1977 Sep 1;146(3):641–652. doi: 10.1084/jem.146.3.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Giddon D. B., Lindhe J. In vivo quantitation of local anesthetic suppression of leukocyte adherence. Am J Pathol. 1972 Aug;68(2):327–338. [PMC free article] [PubMed] [Google Scholar]
  6. Goldstein I. M., Lind S., Hoffstein S., Weissmann G. Influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. Reduction of lysosomal enzyme release and superoxide anion production. J Exp Med. 1977 Aug 1;146(2):483–494. doi: 10.1084/jem.146.2.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kitchens C. S., Weiss L. Ultrastructural changes of endothelium associated with thrombocytopenia. Blood. 1975 Oct;46(4):567–578. [PubMed] [Google Scholar]
  8. McDonald T. P., Clift R. Mechanism of thrombocytopenia induced in mice by anti-platelet serum. Haemostasis. 1976;5(1):38–50. doi: 10.1159/000214117. [DOI] [PubMed] [Google Scholar]
  9. Stewart G. J., Ritchie W. G., Lynch P. R. Venous endothelial damage produced by massive sticking and emigration of leukocytes. Am J Pathol. 1974 Mar;74(3):507–532. [PMC free article] [PubMed] [Google Scholar]
  10. Ubatuba F. B., Harvey E. A., Ferreira S. H. Are platelets important in inflammation? Agents Actions. 1975 Feb;5(1):31–34. doi: 10.1007/BF02027155. [DOI] [PubMed] [Google Scholar]
  11. Wautier J. L., Souchon H., Solal L. C., Peltier A. P., Caen J. P. C1 and human platelets. III. Role of C1 subcomponents in platelet aggregation induced by aggregated IgG. Immunology. 1976 Oct;31(4):595–599. [PMC free article] [PubMed] [Google Scholar]
  12. Zweifach B. W. Current concepts of microcirculatory behavior. Bibl Anat. 1965;7:2–8. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES