Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1979 Jul;32(7):655–659. doi: 10.1136/jcp.32.7.655

An improved method for the measurement of red cell survival using non-radioactive chromium.

H C Drysdale, P M Emerson, A Holmes
PMCID: PMC1145771  PMID: 500836

Abstract

An improved technique for the measurement of red cell survival is described in which non-radioactive 50Cr is used in patients for whom radioactive labels are not advisable. The 50Cr was measured by neutron activation analysis using a high resolution germanium (lithium) diode gamma-ray spectrometer. In adult controls, the values obtained were in the range accepted as normal for the 51Cr method, and double labelling experiments showed close agreement. The application of this technique to the measurement of red cell survival in pregnant women suspected of having haemolytic anemia is described.

Full text

PDF
655

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANWAR R. A., LANGHAM R. F., HOPPERT C. A., ALFREDSON B. V., BYERRUM R. U. Chronic toxicity studies. III. Chronic toxicity of cadmium and chromium in dogs. Arch Environ Health. 1961 Oct;3:456–460. doi: 10.1080/00039896.1961.10663050. [DOI] [PubMed] [Google Scholar]
  2. Donaldson G. W., Johnson P. F., Tothill P., Richmond J. Red cell survival time in man measured by 50Cr and activation analysis. Br Med J. 1968 Jun 8;2(5605):585–587. doi: 10.1136/bmj.2.5605.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. EBAUGH F. G., Jr, EMERSON C. P., ROSS J. F. The use of radioactive chromium 51 as an erythrocyte tagging agent for the determination or red cell survival in vivo. J Clin Invest. 1953 Dec;32(12):1260–1276. doi: 10.1172/JCI102855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Glomski C. A., Pillay K. K., Macdougall L. G. Erythrocyte survival in children as studied by labeling with stable 50Cr. Am J Dis Child. 1976 Nov;130(11):1228–1230. doi: 10.1001/archpedi.1976.02120120062010. [DOI] [PubMed] [Google Scholar]
  5. Johnson P. F., Tothill P., Donaldson G. W. Stable chromium as a tracer for red cells, with assay by neutron activation analysis. Int J Appl Radiat Isot. 1969 Feb;20(2):103–108. doi: 10.1016/0020-708x(69)90146-x. [DOI] [PubMed] [Google Scholar]
  6. NECHELES T. F., WEINSTEIN I. M., LEROY G. V. Radioactive sodium chromate for the study of survival of red blood cells. I. The effect of radioactive sodium chromate on red cells. J Lab Clin Med. 1953 Sep;42(3):358–367. [PubMed] [Google Scholar]
  7. Nathan D. G., Oski F. A., Miller D. R., Gardner F. H. Life-span and organ sequestration of the red cells in pyruvate kinase deficiency. N Engl J Med. 1968 Jan 11;278(2):73–81. doi: 10.1056/NEJM196801112780203. [DOI] [PubMed] [Google Scholar]
  8. Uchiyama G., Akiba H., Kakehi H. Determination of red cell survival by activation analysis. Int J Nucl Med Biol. 1975 Jan;2(1):37–40. doi: 10.1016/0047-0740(75)90019-4. [DOI] [PubMed] [Google Scholar]
  9. VISEK W. J., WHITNEY I. B., KUHN U. S., 3rd, COMAR C. L. Metabolism of Cr51 by animals as influenced by chemical state. Proc Soc Exp Biol Med. 1953 Dec;84(3):610–615. doi: 10.3181/00379727-84-20729. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES