Abstract
The inter- and intra-observer reproducibility of three grading systems for breast cancer has been analysed: those of the World Health Organisation, of Black, and of Hartveit. In addition, the components forming the basis of these grading systems were analysed separately with regard to reproducibility and interrelationship. In this analysis, degree of differentiation was also included as a parameter. The grading systems of WHO and of Black gave a stratification of the material into three categories of tumours, but that of Hartveit did not. All three systems had a low inter- and intra-observer reproducibility. Truncated component analysis indicated that the grading systems of WHO and of Black are closely related to each other and to the 'nuclear lobulation' component of Hartveit's system. The components 'pleomorphism', 'mitotic frequency', and 'hyperchromasia' of the WHO system were closely interrelated. Descriptors such as 'differentiation' and 'tubule formation' were interrelated but acted in a different direction from the others.
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Selected References
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- BLACK M. M., SPEER F. D. Nuclear structure in cancer tissues. Surg Gynecol Obstet. 1957 Jul;105(1):97–102. [PubMed] [Google Scholar]
- BLOOM H. J., RICHARDSON W. W. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 1957 Sep;11(3):359–377. doi: 10.1038/bjc.1957.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cutler S. J., Black M. M., Friedell G. H., Vidone R. A., Goldenberg I. S. Prognostic factors in cancer of the female breast. II. Reproducibility of histopathologic classification. Cancer. 1966 Jan;19(1):75–82. doi: 10.1002/1097-0142(196601)19:1<75::aid-cncr2820190108>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
- Hartveit F. Prognostic typing in breast cancer. Br Med J. 1971 Oct 30;4(5782):253–257. doi: 10.1136/bmj.4.5782.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAISER H. F., CAFFREY J. ALPHA FACTOR ANALYSIS. Psychometrika. 1965 Mar;30:1–14. doi: 10.1007/BF02289743. [DOI] [PubMed] [Google Scholar]
- Kister S. J., Sommers S. C., Haagenses C. D., Friedell G. H., Cooley E., Varma A. Nuclear grade and sinus histiocytosis in cancer of the breast. Cancer. 1969 Mar;23(3):570–575. doi: 10.1002/1097-0142(196903)23:3<570::aid-cncr2820230307>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
- LEWISON E. F., TRIMBLE F. H., GRIFFITH P. C. Results of surgical treatment of breast cancer at Johns Hopkins Hospital, 1935-1940. J Am Med Assoc. 1953 Nov 7;153(10):905–909. doi: 10.1001/jama.1953.02940270011003. [DOI] [PubMed] [Google Scholar]