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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1979 Oct;32(10):1036–1040. doi: 10.1136/jcp.32.10.1036

EB virus-specific IgA in serum of patients with infectious mononucleosis and of healthy people of different ages.

J M Edwards, M Woodroof
PMCID: PMC1145887  PMID: 230203

Abstract

The following sera were tested for EB virus-specific IgA: serial sera from 61 cases of infectious mononucleosis (IM) and from 195 EBV IgG positive healthy students; single sera from each of 1469 persons of different ages, 63 cases of untreated Hodgkin's disease, and 22 neonates. EBV specific IgA was found in the sera from 88% of cases of IM, from 18.5% of EBV IgG positive healthy students, and in 13.5% of repeat samples from the same students three years later. The incidence of EBV IgA varied from 5 to 30% at different ages in single sera from EBV IgG positive persons aged 2 to 70 years. The higher percentages occurred in the age groups where recent sero-conversion rates were high. Fifteen percent of sera from cases of Hodgkin's disease were positive for EBV IgA, an incidence similar to that for healthy adults in the age group 25-45 years. None of the EBV IgG positive sera from neonates gave a positive reaction for EBV IGA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blake J. M., Edwards J. M., Fletcher W., McSwiggan D. A., Pereira M. S. Measurement of heterophil antibody and antibodies to EB viral capsid antigen IgG and IgM in suspected cases of infectious mononucleosis. J Clin Pathol. 1976 Sep;29(9):841–847. doi: 10.1136/jcp.29.9.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Edwards J. M., McSwiggan D. A. Studies on the diagnostic value of an immunofluorescence test for EB virus-specific IgM. J Clin Pathol. 1974 Aug;27(8):647–651. doi: 10.1136/jcp.27.8.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Henle G., Henle W. Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. Int J Cancer. 1976 Jan 15;17(1):1–7. doi: 10.1002/ijc.2910170102. [DOI] [PubMed] [Google Scholar]
  4. Ho H. C., Kwan H. C., Ng M. H., de The G. Serum IgA antibodies to Epstein-Barr virus capsid antigen preceding symptoms of nasopharyngeal carcinoma. Lancet. 1978 Feb 25;1(8061):436–436. doi: 10.1016/s0140-6736(78)91220-5. [DOI] [PubMed] [Google Scholar]
  5. Ho H. C., Ng M. H., Kwan H. C., Chau J. C. Epstein-Barr-virus-specific IgA and IgG serum antibodies in nasopharyngeal carcinoma. Br J Cancer. 1976 Dec;34(6):655–660. doi: 10.1038/bjc.1976.228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hoskins T. W., Fletcher W. B., Blake J. M., Pereira M. S., Edwards J. M. EB virus antibody and infectious mononucleosis in a boarding school for boys. J Clin Pathol. 1976 Jan;29(1):42–45. doi: 10.1136/jcp.29.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Joncas J., Boucher J., Granger-Julien M., Filion C. Epstein-Barr virus infection in the neonatal period and in childhood. Can Med Assoc J. 1974 Jan 5;110(1):33–37. [PMC free article] [PubMed] [Google Scholar]
  8. Mawhinney H., Haire M., Adair B. M. The use of cord serum and indirect viral immunofluorescence as a method of evaluating the immunological specificity of fluorescein-labelled anti-human IgA conjugate. J Immunol Methods. 1973 Apr;2(3):309–313. doi: 10.1016/0022-1759(73)90057-4. [DOI] [PubMed] [Google Scholar]
  9. Miller G., Niederman J. C., Andrews L. L. Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis. N Engl J Med. 1973 Feb 1;288(5):229–232. doi: 10.1056/NEJM197302012880503. [DOI] [PubMed] [Google Scholar]
  10. Muñoz N., Davidson R. J., Witthoff B., Ericsson J. E., De-Thé G. Infectious mononucleosis and Hodgkin's disease. Int J Cancer. 1978 Jul 15;22(1):10–13. doi: 10.1002/ijc.2910220104. [DOI] [PubMed] [Google Scholar]
  11. Pereira M. S., Blake J. M., Macrae A. D. EB virus antibody at different ages. Br Med J. 1969 Nov 29;4(5682):526–527. doi: 10.1136/bmj.4.5682.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rosdahl N., Larsen S. O., Clemmesen J. Hodgkin's disease in patients with previous infectious mononucleosis: 30 years' experience. Br Med J. 1974 May 4;2(5913):253–256. doi: 10.1136/bmj.2.5913.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sumaya C. V., Henle W., Henle G., Smith M. H., LeBlanc D. Seroepidemiologic study of Epstein-Barr virus infections in a rural community. J Infect Dis. 1975 Apr;131(4):403–408. doi: 10.1093/infdis/131.4.403. [DOI] [PubMed] [Google Scholar]

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