Abstract
C-reactive protein, measured in serum from 38 patients with leukaemia, was elevated to at least 100 mg/l at the beginning of 32 of 34 episodes of infection, and subsequently rose above 100 mg/l in all 34. Uninfected patients, whether in leukaemic remission or relapse and whether pyrexial or not, always had levels below 100 mg/l, with four exceptions out of 290 measurements. Estimation of two other acute-phase proteins, alpha 1-antitrypsin and orosomucoid, was not of additional diagnostic value. Serial measurement of C-reactive protein may be important for the early detection of infection in the leukaemic patient with neutropenia.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Crockson R. A., Payne C. J., Ratcliff A. P., Soothill J. F. Time sequence of acute phase reactive proteins following surgical trauma. Clin Chim Acta. 1966 Oct;14(4):435–441. doi: 10.1016/0009-8981(66)90030-1. [DOI] [PubMed] [Google Scholar]
- HOKAMA Y., RILEY R. F. Purification of C-reactive protein, an acute phase protein of human serum. Biochim Biophys Acta. 1963 Jul 16;74:305–308. doi: 10.1016/0006-3002(63)91371-4. [DOI] [PubMed] [Google Scholar]
- Mackie P. H., Mistry D. K., Wozniak J. T., Dodds W. N., Geddes A. M., Stuart J. Neutrophil cytochemistry in bacterial infection. J Clin Pathol. 1979 Jan;32(1):26–30. doi: 10.1136/jcp.32.1.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- Martinez L. A., Quintiliani R., Tilton R. C. Clinical experience on the detection of endotoxemia with the limulus test. J Infect Dis. 1973 Jan;127(1):102–105. doi: 10.1093/infdis/127.1.102. [DOI] [PubMed] [Google Scholar]
- McConkey B., Crockson R. A., Crockson A. P. The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants. Q J Med. 1972 Apr;41(162):115–125. [PubMed] [Google Scholar]
- RAPPORT M. M., SCHWARTZ A. E., GRAF L. C-reactive protein in patients following operation. Ann Surg. 1957 Mar;145(3):321–325. doi: 10.1097/00000658-195703000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steigbigel R. T., Johnson P. K., Remington J. S. The nitroblue tetrazolium reduction test versus conventional hematology in the diagnosis of bacterial infection. N Engl J Med. 1974 Jan 31;290(5):235–238. doi: 10.1056/NEJM197401312900501. [DOI] [PubMed] [Google Scholar]
- Werner M. Serum protein changes during the acute phase reaction. Clin Chim Acta. 1969 Aug;25(2):299–305. doi: 10.1016/0009-8981(69)90272-1. [DOI] [PubMed] [Google Scholar]
- Yen-Watson B., Kushner I. Rabbit CRP response to endotoxin administration: dose-response relationship and kinetics. Proc Soc Exp Biol Med. 1974 Sep;146(4):1132–1136. doi: 10.3181/00379727-146-38260. [DOI] [PubMed] [Google Scholar]