Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1979 Dec;32(12):1282–1285. doi: 10.1136/jcp.32.12.1282

Liver damage due to perhexiline maleate.

G B Forbes, M O Rake, D J Taylor
PMCID: PMC1145951  PMID: 536463

Abstract

Two middle-aged men, who had received perhexiline in recommended dosage, showed clinical and histological evidence of severe hepatic damage, and one of them died. Histological study of the livers showed a striking resemblance to alcoholic hepatitis.

Full text

PDF
1282

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beaugrand M., Chousterman M., Callard P., Camilleri J. P., Petite J., Ferrier J. P. Hépatites au maléate de perhexiline (Pexid). Evoluant vers la cirrhose malgré l'arrêt du traitement (2 cas). Gastroenterol Clin Biol. 1977 Oct;1(10):745–750. [PubMed] [Google Scholar]
  2. Bonnet P., Jourdan J., Janbon F., Michel H., Bertrand A. Cirrhose hépatique après deux ans de traitement par le maléate de perhexiline. Nouv Presse Med. 1978 Jan 21;7(3):208–208. [PubMed] [Google Scholar]
  3. Lewis D., Wainwright H. C., Kew M. C., Zwi S., Isaacson C. Liver damage associated with perhexiline maleate. Gut. 1979 Mar;20(3):186–189. doi: 10.1136/gut.20.3.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lockhart J. D., Masheter H. C. Report of a multicentre monitored release study of perhexiline maleate in the prevention of angina pectoris. Br J Clin Pract. 1976 Sep;30(9):172–177. [PubMed] [Google Scholar]
  5. McDonald G. S. Liver damage after perhexiline maleate. Lancet. 1977 May 14;1(8020):1056–1056. doi: 10.1016/s0140-6736(77)91290-9. [DOI] [PubMed] [Google Scholar]
  6. Pelletier M., Lambert R., Paliard P., Bory R. Hépatite toxique subaiguë après traitement par maléate de perhexiline. Nouv Presse Med. 1976 Apr 17;5(16):1070–1070. [PubMed] [Google Scholar]
  7. Pessayre D., Bichara M., Degott C., Potet F., Benhamou J. P., Feldmann G. Perhexiline maleate-induced cirrhosis. Gastroenterology. 1979 Jan;76(1):170–177. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES