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. 1980 Feb;33(2):160–162. doi: 10.1136/jcp.33.2.160

Substance P in ovarian carcinoid.

P Skrabanek, P Dervan, D Cannon, D Powell
PMCID: PMC1146012  PMID: 6154065

Abstract

A high content of substance P (124 ng/g wet tissue) was demonstrated by radioimmunoassay in lymph node metastases in a patient with bilateral ovarian carcinoid tumours. The plasma substance P level was elevated but urinary 5-hydroxyindoleacetic acid (5-HIAA) was low. It is suggested that, in some carcinoid patients, an elevated plasma substance P level may help diagnosis and follow-up when urinary 5-HIAA is normal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alumets J., Håkanson R., Ingemansson S., Sundler F. Substance P and 5-HT in granules isolated from an intestinal argentaffin carcinoid. Histochemistry. 1977 Jun 8;52(3):217–222. doi: 10.1007/BF00495858. [DOI] [PubMed] [Google Scholar]
  2. Cannon D., Skrabanek P., Powell D., Harrington M. G. Immunological characterization of two substance-P antisera with substance-P fragments and analogues [proceedings]. Biochem Soc Trans. 1977;5(6):1736–1738. doi: 10.1042/bst0051736. [DOI] [PubMed] [Google Scholar]
  3. Chang M. M., Leeman S. E. Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P. J Biol Chem. 1970 Sep 25;245(18):4784–4790. [PubMed] [Google Scholar]
  4. Coll R. P., Young R. H., Jagoe W. S., Hennessy T. P. Sequential development of bilateral ovarian carcinoids. Ir J Med Sci. 1977 Nov;146(11):390–392. doi: 10.1007/BF03030995. [DOI] [PubMed] [Google Scholar]
  5. Heitz P., Polak J. M., Kasper M., Timson C. M., Pearse A. G. Immunoelectron cytochemical localization of motilin and substance P in rabbit bile duct enterochromaffin (EC) cells. Histochemistry. 1977 Feb 1;50(4):319–325. doi: 10.1007/BF00507125. [DOI] [PubMed] [Google Scholar]
  6. O'Connell R., Skrabanek P., Cannon D., Powell D. High-sensitivity radioimmunoassay for substance P. Ir J Med Sci. 1976 Dec;145(12):392–398. [PubMed] [Google Scholar]
  7. Powell D., Skrabanek P. Brain and gut. Clin Endocrinol Metab. 1979 Jul;8(2):299–312. doi: 10.1016/s0300-595x(79)80043-2. [DOI] [PubMed] [Google Scholar]
  8. Skrabanek P., Cannon D., Dempsey J., Kirrane J., Neligan M., Powell D. Substance P in medullary carcinoma of the thyroid. Experientia. 1979 Sep 15;35(9):1259–1260. doi: 10.1007/BF01963325. [DOI] [PubMed] [Google Scholar]
  9. Skrabanek P., Cannon D., Kirrane J., Legge D., Powell D. Circulating immunoreactive substance P in man. Ir J Med Sci. 1976 Dec;145(12):399–408. [PubMed] [Google Scholar]
  10. Skrabanek P., Cannon D., Kirrane J., Powell D. Substance P secretion by carcinoid tumours. Ir J Med Sci. 1978 Feb;147(2):47–49. doi: 10.1007/BF02939369. [DOI] [PubMed] [Google Scholar]
  11. V Euler U. S., Gaddum J. H. An unidentified depressor substance in certain tissue extracts. J Physiol. 1931 Jun 6;72(1):74–87. doi: 10.1113/jphysiol.1931.sp002763. [DOI] [PMC free article] [PubMed] [Google Scholar]

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