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. 1980 Jul;33(7):622–625. doi: 10.1136/jcp.33.7.622

Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism.

M W Kenny, A J George, J Stuart
PMCID: PMC1146172  PMID: 7430367

Abstract

Platelet function was measured on 29 occasions in 16 adult patients in the asymptomatic steady state of sickle-cell anaemia. There was a significant increase in platelet number and micro-aggregate formation, and a lower aggregation threshold with adenosine diphosphate, compared with 23 healthy controls. Similar changes were found, however, in 12 splenectomised patients without sickle-cell diseases. The platelet hyperactivity of the sickle-cell steady state therefore reflects an increased circulating population of young, metabolically active platelets resulting from previous autosplenectomy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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