Abstract
A sensitive radioimmunoassay method for HBeAg and anti-HBe allowed 98.4% of HBsAg positive blood donors to be classified. HBeAg was more prevalent in blood donors under 30 years of age and anti-HBe was more prevalent in those over 30 years. The mean HBsAg concentration was four times greater in donors with HBeAg than in those with anti-HBe. No significant associations were found with sex, blood groups, or HBsAg subtypes. It is likely that this test system will be extremely useful to blood transfusion centres and hepatitis reference laboratories in the future.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barr A., Black S. H., Burrell C. J., Dow B., Macvarish I. Hepatitis Be antigen and antibody in hepatitis B surface antigen positive blood donors. J Clin Pathol. 1979 Feb;32(2):132–135. doi: 10.1136/jcp.32.2.132. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Couroucé-Pauty A. M., Plançon A. e-Antigen and anti-e in two categories of chronic carriers of hepatitis B surface antigen. Vox Sang. 1978;34(4):231–238. doi: 10.1111/j.1423-0410.1978.tb02473.x. [DOI] [PubMed] [Google Scholar]
- Magnius L. O., Espmark J. A. New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants. J Immunol. 1972 Nov;109(5):1017–1021. [PubMed] [Google Scholar]
- Magnius L. O., Lindholm A., Lundin P., Iwarson S. A new antigen-antibody system. Clinical significance in long-term carriers of hepatitis B surface antigen. JAMA. 1975 Jan 27;231(4):356–359. doi: 10.1001/jama.231.4.356. [DOI] [PubMed] [Google Scholar]
- Ohbayashi A., Matsuo Y., Mozai T., Imai M., Mayumi M. Letter: Decreasing frequency of e antigen with age in serum of symptom-free carriers of hepatitis B antigen. Lancet. 1976 Sep 11;2(7985):577–578. doi: 10.1016/s0140-6736(76)91829-8. [DOI] [PubMed] [Google Scholar]
- Okada K., Kamiyama I., Inomata M., Imai M., Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976 Apr 1;294(14):746–749. doi: 10.1056/NEJM197604012941402. [DOI] [PubMed] [Google Scholar]
- Tachibana C. F., Baba K., Fukuda M., Imai M., Miyakawa Y., Mayumi M. High prevalence of e antigen among healthy blood donors carrying hepatitis B surface antigen in Japan. Vox Sang. 1977;32(5):296–299. doi: 10.1111/j.1423-0410.1977.tb00649.x. [DOI] [PubMed] [Google Scholar]
- Ukkonen P., Koistinen V., Penttinen K. Anti-HBe and subtypes of HBsAg among asymptomatic HBsAg carriers. Vox Sang. 1979;36(2):109–114. doi: 10.1111/j.1423-0410.1979.tb04409.x. [DOI] [PubMed] [Google Scholar]