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. 1980 Nov;33(11):1110–1113. doi: 10.1136/jcp.33.11.1110

Phagocytosis of neutrophil polymorphonuclears by macrophages in human bone marrow: importance in granulopoiesis.

C Dresch, G Flandrin, J Breton-Gorius
PMCID: PMC1146347  PMID: 7440759

Abstract

The cytological and electron-microscopic appearance of aneutrophil phagocytosis by macrophages in normal human bone marrow is described. This feature can be observed in every normal bone marrow and is especially frequent in autoimmune disease. Bone marrrow phagocytosis of polymorphonuclear neutrophils seems to be a physiological process resulting from the random egress of neutrophils from bone marrow to blood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BREWER D. B. ELECTRON-MICROSCOPE OBSERVATIONS ON THE PHAGOCYTOSIS OF NEUTROPHIL POLYMORPHONUCLEAR LEUCOCYTES BY MACROPHAGES. J Pathol Bacteriol. 1964 Jul;88:307–309. doi: 10.1002/path.1700880139. [DOI] [PubMed] [Google Scholar]
  2. Boll I. T., Fuchs G. A kinetic model of granulocytopoiesis. Exp Cell Res. 1970 Jul;61(1):147–152. doi: 10.1016/0014-4827(70)90268-5. [DOI] [PubMed] [Google Scholar]
  3. Breton-Gorius J., Houssay D., Dreyfus B. Partial myeloperoxidase deficiency in a case of preleukaemia. I. Studies of fine structure and peroxidase synthesis of promyelocytes. Br J Haematol. 1975 Jul;30(3):273–278. doi: 10.1111/j.1365-2141.1975.tb00542.x. [DOI] [PubMed] [Google Scholar]
  4. CARTWRIGHT G. E., ATHENS J. W., WINTROBE M. M. THE KINETICS OF GRANULOPOIESIS IN NORMAL MAN. Blood. 1964 Dec;24:780–803. [PubMed] [Google Scholar]
  5. Clarkson B., Ohkita T., Ota K., Fried J. Studies of cellular proliferation in human leukemia. I. Estimation of growth rates of leukemic and normal hematopoietic cells in two adults with acute leukemia given single injections of tritiated thymidine. J Clin Invest. 1967 Apr;46(4):506–529. doi: 10.1172/JCI105553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DONOHUE D. M., REIFF R. H., HANSON M. L., BETSON Y., FINCH C. A. Quantitative measurement of the erythrocytic and granulocytic cells of the marrow and blood. J Clin Invest. 1958 Nov;37(11):1571–1576. doi: 10.1172/JCI103750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dancey J. T., Deubelbeiss K. A., Harker L. A., Finch C. A. Neutrophil kinetics in man. J Clin Invest. 1976 Sep;58(3):705–715. doi: 10.1172/JCI108517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Deubelbeiss K. A., Dancey J. T., Harker L. A., Finch C. A. Neutrophil kinetics in the dog. J Clin Invest. 1975 Apr;55(4):833–839. doi: 10.1172/JCI107994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dresch C., Faille A., Bauchet J., Najean V. Studies of granulocyte kinetics in normal and granulocytopenic subjects. Biomedicine. 1975 Mar;22(2):145–157. [PubMed] [Google Scholar]
  10. Dresch C., Najean Y., Bauchet J. Kinetic studies of 51Cr and DF32P labelled granulocytes. Br J Haematol. 1975 Jan;29(1):67–80. doi: 10.1111/j.1365-2141.1975.tb01800.x. [DOI] [PubMed] [Google Scholar]
  11. FLIEDNER T. M., CRONKITE E. P., KILLMANN S. A., BOND V. P. GRANULOCYTOPOIESIS. II. EMERGENCE AND PATTERN OF LABELING OF NEUTROPHILIC GRANULOCYTES IN HUMANS. Blood. 1964 Dec;24:683–700. [PubMed] [Google Scholar]
  12. Graham R. C., Jr, Karnovsky M. J. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem. 1966 Apr;14(4):291–302. doi: 10.1177/14.4.291. [DOI] [PubMed] [Google Scholar]
  13. HARRISON W. J. The total cellularity of the bone marrow in man. J Clin Pathol. 1962 May;15:254–259. doi: 10.1136/jcp.15.3.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kimball H. R., Wolff S. M., Talal N., Plotz P. H., Decker J. L. Marrow granulocyte reserves in the rheumatic diseases. Arthritis Rheum. 1973 May-Jun;16(3):345–352. doi: 10.1002/art.1780160308. [DOI] [PubMed] [Google Scholar]
  15. Mathy K. A., Koepke J. A. The clinical usefulness of segmented vs. stab neutrophil criteria for differential leukocyte counts. Am J Clin Pathol. 1974 Jun;61(6):947–958. [PubMed] [Google Scholar]
  16. Meuret G., Bammert J., Gessner U. Neutrophil marrow release. A system analysis. Blut. 1976 Dec;33(6):389–402. doi: 10.1007/BF00996571. [DOI] [PubMed] [Google Scholar]
  17. Mishler J. M., Sharp A. A. Adrenaline: further discussion of its role in the mobilization of neutrophils. Scand J Haematol. 1976 Jul;17(1):78–80. doi: 10.1111/j.1600-0609.1976.tb02844.x. [DOI] [PubMed] [Google Scholar]
  18. Steinbach K. H., Schick P., Trepel F., Raffler H., Döhrmann J., Heilgeist G., Heltzel W., Li K., Past W., van der Woerd-de Lange J. A. Estimation of kinetic parameters of neutrophilic, eosinophilic, and basophilic granulocytes in human blood. Blut. 1979 Jul;39(1):27–38. doi: 10.1007/BF01008072. [DOI] [PubMed] [Google Scholar]

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