Abstract
The distribution of four antigens of alimentary tract origin was studied in meconium collected from healthy and cystic fibrosis (CF) neonates. Two antigens, carcinoembryonic antigen and a beta glycoprotein designated Mec 6, had significantly lower concentrations in the meconium from CF neonates compared with that from healthy full-term infants. As their concentrations were unrelated to whether or not the infants had had pancreatic insufficiency at birth, their measurement may be of value for screening. Their concentrations also depended on the gestational age of the newborn, and it is speculated that the CF lesion may affect the maturation of intestinal secretions.
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- Antonowicz I., Ishida S., Shwachman H. Studies in meconium in cystic fibrosis: the activities of alpha-D-mannosidase, beta-glucuronidase, beta-D-fucosidase, acid and alkaline phosphatase. Biol Neonate. 1978;34(5-6):225–230. doi: 10.1159/000241133. [DOI] [PubMed] [Google Scholar]
- Antonowicz I., Ishida S., Shwachman H. Studies in meconium: disaccharidase activities in meconium from cystic fibrosis patients and controls. Pediatrics. 1975 Nov;56(5):782–787. [PubMed] [Google Scholar]
- Kroll J., Andersen M. M. Specific antisera produced by immunization with precipitin lines. J Immunol Methods. 1976;13(2):125–130. doi: 10.1016/0022-1759(76)90150-2. [DOI] [PubMed] [Google Scholar]
- Prosser R., Owen H., Bull F., Parry B., Smerkinich J., Goodwin H. A., Dathan J. Screening for cystic fibrosis by examination of meconium. Arch Dis Child. 1974 Aug;49(8):597–601. doi: 10.1136/adc.49.8.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ryley H. C. Immunoelectrophoretic analysis of human meconium antigens of non-plasma origin. J Chromatogr. 1977 Jul 1;143(4):411–414. doi: 10.1016/s0378-4347(00)80988-3. [DOI] [PubMed] [Google Scholar]
- Ryley H. C., Neale L. M., Brogan T. D., Bray P. T. Screening for cystic fibrosis by analysis of meconium for albumin and protease inhibitors. Clin Chim Acta. 1975 Oct 15;64(2):117–125. doi: 10.1016/0009-8981(75)90193-x. [DOI] [PubMed] [Google Scholar]
- Wood R. E., Boat T. F., Doershuk C. F. Cystic fibrosis. Am Rev Respir Dis. 1976 Jun;113(6):833–878. doi: 10.1164/arrd.1976.113.6.833. [DOI] [PubMed] [Google Scholar]