Abstract
The use of monoclonal antibodies which can be raised to antigens of choice offers a selective and specific approach for the detection of tumours both in vivo and at a cellular level in biopsy specimens. We demonstrate that a monoclonal antibody raised to human teratoma will localise in a teratoma, growing as a xenograft in immune-suppressed mice.
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Selected References
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- Ballou B., Levine G., Hakala T. R., Solter D. Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy. Science. 1979 Nov 16;206(4420):844–847. doi: 10.1126/science.493985. [DOI] [PubMed] [Google Scholar]
- Coombes R. C., Powles T. J., Gazet J. C., Nash A. G., Ford H. T., McKinna A., Neville A. M. Assessment of biochemical tests to screen for metastases in patients with breast cancer. Lancet. 1980 Feb 9;1(8163):296–297. doi: 10.1016/s0140-6736(80)90790-4. [DOI] [PubMed] [Google Scholar]
- Dykes P. W., Hine K. R., Bradwell A. R., Blackburn J. C., Reeder T. A., Drolc Z., Booth S. N. Localisation of tumour deposits by external scanning after injection of radiolabelled anti-carcinoembryonic antigen. Br Med J. 1980 Jan 26;280(6209):220–222. doi: 10.1136/bmj.280.6209.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldenberg D. M., DeLand F., Kim E., Bennett S., Primus F. J., van Nagell J. R., Jr, Estes N., DeSimone P., Rayburn P. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N Engl J Med. 1978 Jun 22;298(25):1384–1386. doi: 10.1056/NEJM197806222982503. [DOI] [PubMed] [Google Scholar]
- Goldenberg D. M., Kim E. E., DeLand F. H., Bennett S., Primus F. J. Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Res. 1980 Aug;40(8 Pt 2):2984–2992. [PubMed] [Google Scholar]
- Köhler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975 Aug 7;256(5517):495–497. doi: 10.1038/256495a0. [DOI] [PubMed] [Google Scholar]
- Sloane J. P., Ormerod M. G., Neville A. M. Potential pathological application of immunocytochemical methods to the detection of micrometastases. Cancer Res. 1980 Aug;40(8 Pt 2):3079–3082. [PubMed] [Google Scholar]