Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1986 Feb 15;234(1):229–231. doi: 10.1042/bj2340229

Lipolysis in rat adipocytes during recovery from lactation. Response to noradrenaline and adenosine.

R G Vernon, E Finley
PMCID: PMC1146551  PMID: 3707544

Abstract

The replenishment of lipid reserves of adipocytes following the removal of litters from lactating rats is associated with a 3-fold decrease in both the response of lipolysis to noradrenaline and the maximum rate of lipolysis (measured in the presence of noradrenaline plus adenosine deaminase); these adaptations do not appear to result from the changes in serum prolactin and insulin concentrations that occur on litter removal.

Full text

PDF
229

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agius L., Robinson A. M., Girard J. R., Williamson D. H. Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin. Biochem J. 1979 Jun 15;180(3):689–692. doi: 10.1042/bj1800689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aitchison R. E., Clegg R. A., Vernon R. G. Lipolysis in rat adipocytes during pregnancy and lactation. The response to noradrenaline. Biochem J. 1982 Jan 15;202(1):243–247. doi: 10.1042/bj2020243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Amenomori Y., Chen C. L., Meites J. Serum prolactin levels in rats during different reproductive states. Endocrinology. 1970 Mar;86(3):506–510. doi: 10.1210/endo-86-3-506. [DOI] [PubMed] [Google Scholar]
  4. Burnol A. F., Leturque A., Ferré P., Girard J. Glucose metabolism during lactation in the rat: quantitative and regulatory aspects. Am J Physiol. 1983 Oct;245(4):E351–E358. doi: 10.1152/ajpendo.1983.245.4.E351. [DOI] [PubMed] [Google Scholar]
  5. Chohan P., Carpenter C., Saggerson E. D. Changes in the anti-lipolytic action and binding to plasma membranes of N6-L-phenylisopropyladenosine in adipocytes from starved and hypothyroid rats. Biochem J. 1984 Oct 1;223(1):53–59. doi: 10.1042/bj2230053. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dax E. M., Partilla J. S., Gregerman R. I. Increased sensitivity to epinephrine stimulated lipolysis during starvation: tighter coupling of the adenylate cyclase complex. Biochem Biophys Res Commun. 1981 Aug 31;101(4):1186–1192. doi: 10.1016/0006-291x(81)91573-4. [DOI] [PubMed] [Google Scholar]
  7. Flint D. J., Clegg R. A., Vernon R. G. Prolactin and the regulation of adipose-tissue metabolism during lactation in rats. Mol Cell Endocrinol. 1981 May;22(2):265–275. doi: 10.1016/0303-7207(81)90096-4. [DOI] [PubMed] [Google Scholar]
  8. Giudicelli Y., Lacasa D., Agli B. Alterations induced by a prolonged fasting: opposite effects on the beta-adrenergic receptor-coupled adenylate-cyclase system and on lipolysis in fat cells from rat. Eur J Biochem. 1982 Jan;121(2):301–308. doi: 10.1111/j.1432-1033.1982.tb05786.x. [DOI] [PubMed] [Google Scholar]
  9. Hamosh M., Clary T. R., Chernick S. S., Scow R. O. Lipoprotein lipase activity of adipose and mammary tissue and plasma triglyceride in pregnant and lactating rats. Biochim Biophys Acta. 1970 Sep 8;210(3):473–482. doi: 10.1016/0005-2760(70)90044-5. [DOI] [PubMed] [Google Scholar]
  10. Johnson C. L. Some aspects of changing body composition of mice during successive pregnancies and lactations. J Endocrinol. 1973 Jan;56(1):37–46. doi: 10.1677/joe.0.0560037. [DOI] [PubMed] [Google Scholar]
  11. Moore B. J., Brasel J. A. One cycle of reproduction consisting of pregnancy, lactation or no lactation, and recovery: effects on fat pad cellularity in ad libitum-fed and food-restricted rats. J Nutr. 1984 Sep;114(9):1560–1565. doi: 10.1093/jn/114.9.1560. [DOI] [PubMed] [Google Scholar]
  12. Scow R. O., Chernick S. S., Fleck T. R. Lipoprotein lipase and uptake of triacylglycerol, cholesterol and phosphatidylcholine from chylomicrons by mammary and adipose tissue of lactating rats in vivo. Biochim Biophys Acta. 1977 May 25;487(2):297–306. doi: 10.1016/0005-2760(77)90006-6. [DOI] [PubMed] [Google Scholar]
  13. Trayhurn P. Decreased capacity for non-shivering thermogenesis during lactation in mice. Pflugers Arch. 1983 Aug;398(3):264–265. doi: 10.1007/BF00657164. [DOI] [PubMed] [Google Scholar]
  14. Trayhurn P., Richard D. Brown adipose tissue thermogenesis and the energetics of pregnancy and lactation in rodents. Biochem Soc Trans. 1985 Oct;13(5):826–828. doi: 10.1042/bst0130826. [DOI] [PubMed] [Google Scholar]
  15. Vernon R. G., Finley E., Taylor E. Adenosine and the control of lipolysis in rat adipocytes during pregnancy and lactation. Biochem J. 1983 Oct 15;216(1):121–128. doi: 10.1042/bj2160121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Vernon R. G., Flint D. J. Control of fatty acid synthesis in lactation. Proc Nutr Soc. 1983 Jun;42(2):315–331. doi: 10.1079/pns19830035. [DOI] [PubMed] [Google Scholar]
  17. Zapf J., Waldvogel M., Froesch E. R. Increased sensitivity of rat adipose tissue to the lipolytic action of epinephrine during fasting and its reversal during re-feeding. FEBS Lett. 1977 Apr 1;76(1):135–138. doi: 10.1016/0014-5793(77)80137-3. [DOI] [PubMed] [Google Scholar]
  18. Zapf J., Waldvogel M., Froesch E. R. Is increased basal lipolysis in adipose tissue of fasted-refed rats related to cyclic-AMP-dependent mechanisms? Eur J Biochem. 1981 Oct;119(3):453–459. doi: 10.1111/j.1432-1033.1981.tb05629.x. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES