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. 1986 Mar 1;234(2):489–492. doi: 10.1042/bj2340489

Lactate utilization by the neonatal rat brain in vitro. Competition with glucose and 3-hydroxybutyrate.

E Fernández, J M Medina
PMCID: PMC1146593  PMID: 3718483

Abstract

The maximum rates of lactate oxidation and lipogenesis from lactate by early-neonatal brain slices were considerably greater than those for utilization of glucose and 3-hydroxybutyrate at physiological concentrations. Lactate inhibited glucose utilization, but enhanced 3-hydroxybutyrate utilization. 3-Hydroxybutyrate inhibited lactate and glucose utilization. Glucose slightly inhibited oxidation of lactate and 3-hydroxybutyrate, but scarcely enhanced lipogenesis from these substrates.

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Selected References

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