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. 1986 Jul 1;237(1):229–234. doi: 10.1042/bj2370229

Aboral changes in D-glucose transport by human intestinal brush-border membrane vesicles.

M K Bluett, N N Abumrad, N Arab, F K Ghishan
PMCID: PMC1146969  PMID: 3800877

Abstract

D-Glucose transport was investigated in isolated brush-border membrane vesicles from human small intestine. Characteristics of D-glucose transport from the jejunum were compared with that in the mid and terminal ileum. Jejunal and mid-ileal D-glucose transport was Na+-dependent and electrogenic. The transient overshoot of jejunal D-glucose transport was significantly greater than corresponding values in mid-ileum. The terminal ileum did not exhibit Na+-dependent D-glucose transport, but did exhibit Na+-dependent taurocholate transport. Na+-glucose co-transport activity as measured by tracer-exchange experiments was greatest in the jejunum, and diminished aborally. We conclude that D-glucose transport in man is Na+-dependent and electrogenic in the proximal intestine and directly related to the activity of D-glucose-Na+ transporters present in the brush-border membranes. D-Glucose transport in the terminal ileum resembles colonic transport of D-glucose.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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