Fig. 4.

Differentially abundant microorganisms were related to immune function genes

Abbreviations: High: patients in a high-risk group; low: patients in a low-risk group; p-adj, adjusted p value.

(A) Volcano plot showing differential gene expression in patients with different risk group. Threshold: log2 fold change >1, p-adj <0.05. (B) Heat map showing 30 differential immune gene expression (24 upregulated and 6 downregulated) in patients with different risk groups. (C) Bubble plots showing the correlation between 30 differential immune gene expression and 10 differential microorganisms. Spearman correlation significant (p < 0.05) coefficients are labeled in the figure.